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stearic acid/hypoxia
Odkaz sa uloží do schránky
Strana 1 od 19 výsledky
Hypoxia-stimulated reduction of doxyl stearic acids in human red blood cells. Role of hemoglobin.
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Nitroxide free radicals are under active investigation for their potential use as metabolically responsive contrast agents in electron paramagnetic resonance and nuclear magnetic resonance imaging. The metabolism in human red blood cells of lipid-soluble nitroxides, doxyl stearic acids (DSA), has
Cytochalasin delays but does not prevent cell death from anoxia.
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The role of alterations in the cytoskeleton in the anoxic death of cultured hepatocytes was evaluated with the use of cytochalasin B and colchicine. The addition of 50 microM Cytochalasin did, however, reduce the rate of accumulation of dead cells but was without effect on the number of cells that
Intermittent hypoxia exacerbates pancreatic β-cell dysfunction in a mouse model of diabetes mellitus.
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OBJECTIVE
The effects of intermittent hypoxia (IH) on pancreatic function in the presence of diabetes and the underlying mechanisms are unclear. We hypothesized that IH would exacerbate pancreatic β-cell dysfunction and alter the fatty acids in the male Tallyho/JngJ (TH) mouse, a rodent model of
Hypoxia Modulates Effects of Fatty Acids on NES2Y Human Pancreatic β-cells.
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Saturated fatty acids (FAs) induce apoptosis in the human pancreatic NES2Y β-cell line while unsaturated FAs have nearly no detrimental effect. Moreover, unsaturated FAs are capable of inhibiting the pro-apoptotic effect of saturated FAs. Hypoxia is also known to have deleterious effects on β-cells
Two fatty acid desaturases, STEAROYL-ACYL CARRIER PROTEIN Δ9-DESATURASE6 and FATTY ACID DESATURASE3, are involved in drought and hypoxia stress signaling in Arabidopsis crown galls.
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Agrobacterium tumefaciens-derived crown galls of Arabidopsis (Arabidopsis thaliana) contain elevated levels of unsaturated fatty acids and strongly express two fatty acid desaturase genes, ω3 FATTY ACID DESATURASE3 (FAD3) and STEAROYL-ACYL CARRIER PROTEIN Δ9-DESATURASE6 (SAD6). The fad3-2 mutant
Barbiturate attenuation of brain free fatty acid liberation during global ischemia.
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To find a biochemical basis for the increased tolerance of the brain to anoxia during barbiturate anesthesia, we studied whole-brain free fatty acids (FFA) at various times after decapitation of awake and pentobarbital-anesthetized rats. Post-decapitation, the brains were kept at 37 degrees C for 1
Effects of sustained-release composite on the oxygen levels and sediment phosphorus fractions of an urban river in Shanghai.
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The eutrophication of many rivers and lakes is attributed to the anoxia and the increasing internal loading of nutrients from sediment. A novel sustained-release composite (SRC) synthesis of stearic acid and calcium peroxide (CaO2) was applied to supply a water body with oxygen endured in this
Distribution and metabolism of 14C-Sulfoquinovosylacylpropanediol (14C-SQAP) after a single intravenous administration in tumor-bearing mice.
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Sulfoquinovosylacylpropanediol (SQAP) is a novel potent radiosensitizer that inhibits angiogenesis in vivo and results in increased hypoxia and reduced tumor volume. We investigated the distribution, metabolism, and excretion of SQAP in male KSN-nude mice transplanted with a human pulmonary
Inhibition of bioenergetics alters intracellular calcium, membrane composition, and fluidity in a neuronal cell line.
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The effect of inhibited bioenergetics and ATP depletion on membrane composition and fluidity was examined in cultured neuroblastoma-glioma hybrid NG108-15 cells. Sodium cyanide (CN) and 2-deoxyglucose (2-DG) were used to block, oxidative phosphorylation and anaerobic glycolysis, respectively.
Characterization of redox activity in resting and activated mast cells by reduction and reoxidation of lipophilic nitroxides.
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1. We measured redox systems in resting and activated rat peritoneal mast cells under anoxia by using the redox metabolism of free doxyl stearic acid (5DS) and phosphatidylcholine with two 5DS molecules esterified to the glycerol (di5DSPC). 2. In the absence of oxygen, 5DS and di5DSPC were reduced
[Changes in the fatty acid composition of the phospholipids in the internal organs of rats during the modelling of aconitine arrhythmia].
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The changes of phospholipid fatty acid composition of the viscera were investigated in a model of aconitinic arrhythmia in rats by the GC method. Aconitinic arrhythmia leads to a reduction in a proportion of polyenic fatty acids (arachidonic, docosahexaenoic) and to an increase in that of saturated
Myocardial extraction of lactates, non-esterified fatty acids and their fractions in patients with dilated cardiomyopathy at rest and after the cold pressor test.
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A decrease in the myocardial extraction or excretion of lactates indicates its hypoxia. The authors analyzed changes in the extraction of lactates, non-esterified fatty acids (NEFA) and their fractions: C 14:0, C 16:0, C 16:1, C 18:1, C 18:2 in a group of 15 patients with dilated cardiomyopathy (DC)
Effect of Hyperbaric Oxygen Therapy on Fatty Acid Composition and Insulin-like Growth Factor Binding Protein 1 in Adult Insulin-Dependent Diabetes Mellitus Patients: A Pilot Study.
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Arrhythmogenicity of long-chain fatty acids for cultured rat heart myocytes.
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Cultures of beating rat heart myocytes were exposed for 1 h to stearic, oleic, linoleic or arachidonic acid (5 x 10(-5) M at a 2 : 1 or 6 : 1 FFA/albumin ratio) in hypoxic or normoxic medium with or without glucose. After the 1 h exposure the medium was changed again to normoxic medium without FFA
Mechanisms of amino acid release from the isolated anoxic/reperfused rat heart.
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Loss of amino acids into the coronary artery perfusate, which is exacerbated during anoxic stress, may have important implications for the ability of hearts subjected to ischemia or anoxia to recover function during reoxygenation. This work investigates the mechanisms underlying the amino acid
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