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Orthonasal and retronasal but not oral-cavity-only discrimination of vapor-phase fatty acids.

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Discrimination of vapor-phase linoleic, oleic, and stearic fatty acids was studied using triangle tests. For each trial, 2 of the 3 modified odorant delivery containers (MODCs) had the same content and 1 was different. Contents were either mineral oil-diluted linoleic or oleic acids, with mineral

Dynamics and binding affinity of spin-labeled stearic acids in β-lactoglobulin: evidences from EPR spectroscopy and molecular dynamics simulation.

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β-Lactoglobulin (β-LG) is a member of the lipocalin protein family involved in the transport of fatty acids and other small hydrophobic molecules. The main binding site is at a central cavity, referred to as "calyx", formed by the protein β-barrel sandwich. Continuous-wave and pulsed Fourier

Fatty acid effect on sucrose-induced enamel demineralization and cariogenicity of an experimental biofilm-caries model.

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Based on scarce evidence, fatty acids have been described as anticariogenic. The aim was to evaluate the effect of different types of fatty acids on enamel demineralization and on the cariogenic properties of Streptococcus mutans biofilms on a biofilm/caries model. Mature biofilms of S. mutans UA159

Molecular dynamics simulations of heart-type fatty acid binding protein in apo and holo forms, and hydration structure analyses in the binding cavity.

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Intracellular lipid binding proteins (iLBPs) share distinctive features: a rigid protein structure composed of a β-barrel and an α-helix cap, and a large internalized water cluster. Although X-ray crystallographic studies have elucidated the three-dimensional structures of iLBPs, the protein

Superior mesenteric vein thrombosis in a patient with chronic inhalation exposure to stearic Acid.

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A previously healthy 36-year-old man admitted via emergency room with complaint of progressive chronic abdominal pain for 2 weeks. An enhanced computed tomography (CT) scan revealed a total occlusion of the superior mesenteric vein with thrombus and partial thrombosis of main portal vein. However,

Local polarity and hydrogen bonding inside the Sec14p phospholipid-binding cavity: high-field multi-frequency electron paramagnetic resonance studies.

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Sec14p promotes the energy-independent transfer of either phosphatidylinositol (PtdIns) or phosphatidylcholine (PtdCho) between lipid bilayers in vitro and represents the major PtdIns/PtdCho transfer protein in the budding yeast Saccharomyces cerevisiae. Herein, we employ multi-frequency high-field

Oral cavity discrimination of vapor-phase long-chain 18-carbon fatty acids.

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Linoleic, oleic, and stearic fatty acids, presented vapor-phase retronasally, were discriminable from blanks and each other, but the same concentrations, oral-cavity-only (OCO), were not discriminable from blanks. It remained possible that higher concentrations might be discriminable OCO. To

Targeted metabolomics of pellicle and saliva in children with different caries activity.

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Pellicle is the initial proteinaceous layer that is formed almost instantaneously on all solid surfaces in the oral cavity. It is of essential relevance for any interactions and metabolism on the tooth surface. Up to now, there is no information on the metabolome of this structure. Accordingly, the

A Formulation for Suppressing Bitter Taste in the Human Oral Cavity

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A model for oral drug delivery is described for diminishing bitter taste perception. This model involves the encapsulation of a bitter taste stimulus in lipid microspheres, and the subsequent incorporation of these microspheres in rapidly dissolving edible films that include both masking and

Lipid-drug-conjugate (LDC) solid lipid nanoparticles (SLN) for the delivery of nicotine to the oral cavity - Optimization of nicotine loading efficiency.

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Nicotine, obtained from tobacco leaves, has been used to promote the cessation of smoking and reduce the risk of COPD and lung cancer. Incorporating the active in lipid nanoparticles is an effective tool to minimize its irritation potential and to use the particles as intermediate to produce final

A role of the cancer cell membrane fluidity in the cancer metastases: an ESR study.

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AH66F or Yoshida sarcoma (YS) cells were transplanted intraperitoneally into male Donryu rats. Cancer cells obtained from ascites were suspended in saline solution (10(7) cells/ml) after washing. Then, 0.1 ml of each suspension obtained from both strains was injected into the tail vein of 5 rats,

A vaginal drug delivery model.

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Efficient drug delivery at vaginal cavity is often a challenge owing to its peculiar physiological variations including vast differences in pH. Keeping in view this attribute of the target site, the current work was aimed at developing formulation strategies which could overcome this and

Dry powder nasal drug delivery: challenges, opportunities and a study of the commercial Teijin Puvlizer Rhinocort device and formulation.

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OBJECTIVE To discuss the challenges and opportunities for dry powder nasal medications and to put this in to perspective by evaluating and characterizing the performance of the Teijin beclomethasone dipropionate (BDP) dry powder nasal inhaler; providing a baseline for future nasal products

Aggregation behavior of heteroleptic tris(phthalocyaninato) dysprosium complexes with different alkoxy chains in monolayer or multilayer solid films.

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Three heteroleptic tris(phathlocyaninato) dysprosium triple-decker complexes with different alkoxy groups at the peripheral positions of the medium phthalocyanine ligand (Pc)Dy[Pc(OCnH(2n+1))8]Dy(Pc) (n = 4, 8, 16) (I-III) {Pc = unsubstituted phthalocyaninate; Pc(OC4H9)8 =

Incorporation of fluorescent probes into PAMAM dendrimers.

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Interactions of two fluorescent probes 1-(trimethylammoniumphenyl)-6-phenyl-1,3,5 hexatriene p-toluenesulfonate (TMA-DPH) and 12-(9-anthroyloxy) stearic acid (12-AS) with polyamidoamine (PAMAM) dendrimers were studied. Changes in fluorescence intensity and steady-state fluorescence anisotropy of

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