succinic acid/nekróza

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Beta-aryl-succinic acid hydroxamates as dual inhibitors of matrix metalloproteinases and tumor necrosis factor alpha converting enzyme.

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Novel hydroxamate inhibitors of tumor necrosis factor converting enzyme (TACE) and matrix metalloproteases (MMPs) have been synthesized via the Claisen-Ireland rearrangement. Aryl residues have been introduced to fill the enzyme's P1' specificity pocket. The best compound inhibits MMPs and TACE with

Inhibition of mast cell-dependent anaphylaxis by succinic acid.

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We have examined the effect of succinic acid on anaphylaxis. Succinic acid (100 mM) significantly inhibited systemic anaphylaxis induced by compound 48/80 in mice and dose-dependently inhibited local anaphylaxis activated by anti-dinitrophenyl IgE. Further 10 and 100 mM significantly inhibited

[Protective effect of succinic acid on primary cardiomyocyte hypoxia/reoxygenation injury].

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To establish cardiomyocyte hypoxia/reoxygenation injury model by culturing primary cardiomyocytes from suckling SD rats, in order to study the effect of succinic acid on LDH leakage rate cardiomyocyte ischemia/reperfusion injury. Furthermore, flow cytometry and western blot were conducted to detect

[Oxidative phosphorylation in the brain in myocardial necrosis. The effect of emotional stress].

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The formation of ischemic myocardium necrosis is accompanied by a disturbance of respiratory and phosphorylating function in the cortex of cerebral hemispheres. In this case the most considerable changes are revealed with the use of alpha-ketoglutarate as an oxidation substrate. Inhibition of

Tumor necrosis factor-alpha gene polymorphism in reflux nephropathy.

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OBJECTIVE Interstitial scarring contributes to the progression of renal failure in reflux nephropathy. The proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) has been implicated in the disease susceptibility and pathogenesis of several inflammatory diseases promoting interstitial

Effect of sodium ( S)-2-hydroxyglutarate in male, and succinic acid in female Wistar rats against renal ischemia-reperfusion injury, suggesting a role of the HIF-1 pathway

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Background: Ischemia-reperfusion (IR) injury is the main cause of delayed graft function in solid organ transplantation. Hypoxia-inducible factors (HIFs) control the expression of genes related to preconditioning against IR injury. During

[Prospective survey on adverse effects of radiopharmaceuticals].

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In France, radiopharmaceuticals have been considered as drugs since 1992. Few adverse reactions with radiopharmaceuticals were described in the literature. Some authors have reported a rate of 1 to 6 reactions per 100,000 injections. The purpose of the present study was to evaluate the prevalence of

Ischaemia-reperfusion injury in the rat kidney: the effect of preconditioning.

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OBJECTIVE To design and establish a model to examine whether brief periods of renal artery occlusion (ischaemic preconditioning, IP) confers protection from the effects of a subsequent period of ischaemia and reperfusion of the rat kidney. METHODS Ninety rats were randomized into six groups, i.e.

Inflammatory processes in a murine model of intra-abdominal abscess formation.

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Abscess formation has been viewed as a host defense strategy to contain the spread of infection. However, abscesses are also serious and life-threatening manifestations of persisting microbial infection. The initiation of abscess formation, both clinically and experimentally, involves the release of

NTP Toxicology and Carcinogenesis Studies of Tetrahydrofuran (CAS No. 109-99-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).

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Tetrahydrofuran is used as a reaction medium for Grignard and metal hydride reactions; in the synthesis of butyrolactone, succinic acid, and 1,4-butanediol diacelate; in the fabrication of articles for packaging, transporting, and storing of foods; as a solvent for dyes and lacquers; and as a

NTP Toxicology and Carcinogenesis Studies of Succinic Anhydride (CAS No. 108-30-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies).

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Succinic anhydride, a food additive, is also used in the manufacture of polymeric materials, pharmaceuticals, and agricultural and industrial chemicals. NTP Toxicology and Carcinogenesis studies were conducted by administering suspensions of succinic anhydride (97% pure) in corn oil by gavage to

Synthesis and immunological activity of water-soluble thalidomide prodrugs.

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A series of new water-soluble thalidomide prodrugs was prepared. All compounds were derivatized on the nitrogen of the glutarimide ring. Esters of natural amino acids and succinic acid derivatives have been introduced by reaction with the hydroxymethyl thalidomide 2. Nicotinic acid derivatives were

[Pathomorphological and histochemical changes in the liver of rabbits following fractional irradiation with Co-60].

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Two groups of experimental animals, each consisting of 12 rabbits, were subjected to local fractional irradiation with cobalt 60. Group I received the total dose of 2580 R during 13 days, group II - 5100 R during 24 days. The effects of irradiation were estimated on the strength of histological

Jungia sellowii suppresses the carrageenan-induced inflammatory response in the mouse model of pleurisy.

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This study was conducted to explore the anti-inflammatory effect of Jungia sellowii (Asteraceae) using a murine model of pleurisy induced by carrageenan (Cg). This plant is used in southern Brazil to treat inflammatory diseases. J. sellowii leaves were extracted with ethanol/water to obtain the

[Exploration about the protection mechanism of 5-hydroxy-1-methylhydantoin on paraquat poisoning model].

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To investigate the effects of 5-hydroxy-1-methylhydantoin (HMH) on kidney injury induced by paraquat (PQ).Fifteen SPF healthy Kunming mice were randomly divided into normal saline (NS) control group, PQ poisoning model group and HMH intervention group, with

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