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Evaluation of Frailty and Functional Capacity in End-Stage Liver Disease

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The decrease in functional capacity is a finding that affects quality of life in chronic liver diseases. In a study, 6 Minute Walk Test was associated with mortality in patients with cirrhosis and survival was lower in patients walking less than 250 meters. Malnutrition is a common complication of

Safety and Efficacy of Midodrine Hydrochloride in the Management of Refractory Ascites Due to Cirrhosis in Children

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Ascites in liver cirrhosis is explained by increased production of vasoactive substances, such as nitric oxide, carbon monoxide, and endocannabinoids, which cause splanchnic vasodilatation, increased blood flow through this area, and a decrease in peripheral vascular resistance and the effective

Improving Tissue Oxygenation in Breast Reconstruction Surgery

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The purpose of this trial is to evaluate the effects of perioperative hemodynamic therapy (guided by cardiac output monitoring) on tissue oxygenation during (and after) DIEP flap breast reconstruction surgery. We hypothesize that a low-dose, perioperative dobutamine infusion combined with

Assessment of Immediate Postoperative Delirium (IPD) in Adult Patients: Incidence and Etiologic Factors

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Decision to perform this observational study was made due to the lack of information on the local incidence and risk factors for the development of immediate postoperative delirium (IPD). A literature review was done to study the already implicated perioperative causative factors as well as other

IVIG (Gamunex-C) Treatment Study for POTS Subjects

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Gammunex-C, a form of intravenous immunoglobulin (IVIG), is approved for the treatment of chronic inflammatory demyelinating neuropathy (CIDP) or idiopathic thrombocytopenic purpura (ITP). IVIG has been in use for many decades in the treatment of these disorders and many other

PREDICTION OF FLUID RESPONSIVENESS WITH PASSIVE LEG RISING IN PREGNANT PATIENTS WITH SEVERE PREECLAMPSIA

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INTRODUCTION The clinical manifestations of preeclampsia (PE) are the consequence of endothelial dysfunction. [1, 2] Different hemodynamic patterns have been described, which includes: high vascular resistance, cardiac output (CO) alterations, relative hypovolemia, and increased risk for pulmonary

Diagnosis of Ascites in Infants and Children

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Definition : Ascites is the pathologic fluid accumulation within the peritoneal cavity . causes of ascites in infants and children : - Hepatobiliary disorders (cirrhosis, congenital hepatic fibrosis, acute hepatitis B,C ,Budd -chiari syndrome, Bile duct perforation) - Serositis (crohn's disease,

A Study to Systematically Assess the Efficacy and Safety of Intravenous Albumin Infusions in Severe POTS

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Purpose To assess the efficacy and safety of intravenous 5% albumin infusions in severe Postural Orthostatic Tachycardia Syndrome (POTS). Hypothesis Periodic albumin infusions will be effective in treating patients with severe Postural Orthostatic Tachycardia Syndrome (POTS) Justification POTS is

Non-Contrast 4DCT to Detect Pulmonary Thromboembolic Events

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The standard test to diagnose PE is the Pulmonary Computed Tomography Angiogram (CTA). This can be prohibitive with some patients due to the amount of radiation exposure as well as the complications associated with the need to use intravenous (IV) contrast. CTA can detect acute PE with a sensitivity

Reducing Orthostatic Intolerance With Oral Rehydration in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

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We and others have shown that a majority of younger patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have orthostatic intolerance (OI), the inability to tolerate orthostatic stress such as prolonged standing. OI in ME/CFS comprises postural tachycardia syndrome (POTS) in

Serum STREM and MNDA Mointoring in ICU

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A total of 120 patients will be included in the study. Sixty patients are critically ill with evidence of sepsis during ICU stay (sepsis group) and sixty patients are critically ill without evidence of infectious organism (SIRS group). At admission, Patients data include clinical status; SOFA score;

Aldosterone & Sodium Regulation in Postural Tachycardia Syndrome - Screening

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The protocol consists of a screening visit and evaluation of their autonomic nervous system status. The following activities are part of this study. Subjects may stay for 2 nights and 3 study days. Day 0 Participants will be admitted to the Clinical Research Center, their medical history, physical

Efficacy of Ketamine-Propofol for Short Surgical Procedures

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In recent years there has been particular interest in ketamine-propofol for sedation of patients who are candidates for short minimally invasive surgical procedures. In some centers in Canada and the U.S. is, in fact, the first choice of sedation in the ED. There are also publications of their

Dietary Sodium's Effect on Urinary Sodium and Dopamine Excretion in Patients With Postural Tachycardia Syndrome

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Study Day 1 - Start 150 mEq Na+/day diet (POTS patients as inpatients; healthy control subjects with CRC provided outpatient diet); consume 1.5-2 liters of water per day - Start a 24h urine collection (for Na+, K+, Cr, fractionated catecholamines) - Blood work Study Days 2-5 - Continue 24h urine

Dietary Salt in Postural Tachycardia Syndrome

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Study Day 1 - Start 150 mEq Na+/day diet (POTS patients as inpatients; healthy control subjects with CRC provided outpatient diet) - Start a 24h urine collection (for Na+, K+, Cr, fractionated catecholamines) - Blood work - Blood volume - carbon monoxide rebreathing Study Day 2 - Complete 24h

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