A method of treating, preventing or inhibiting a disorder selected from the group consisting of cardiovascular or heart related diseases such as stroke, hypertension, tachycardia, and congestive heart failure, osteoporosis, premature birth, psychosocial dwarfism, stress-induced fever, ulcer, diarrhea, post-operative ileus, and colonic hypersensitivity associated with psychopathological disturbance and stress, comprising administering to a mammal, including a human, in need of such treatment a therapeutically effective amount of a compound of the formula ##STR1##or a pharmaceutically acceptable salt thereof, wherein A, B, D, E, Y, Z, R.sub.3, R.sub.4, and R.sub.5 are as defined herein.

Pfizer Inc

Corticotropin releasing factor antagonists

The present invention provides novel compounds of Formula I ##STR00001## and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells. Such disorders and diseases include, by way of example only, cardiac disorders and diseases, skeletal muscular disorders and diseases, cognitive disorders and diseases, malignant hyperthermia, diabetes, and sudden infant death syndrome. Cardiac disorder and diseases include, but are not limited to, irregular heartbeat disorders and diseases; exercise-induced irregular heartbeat disorders and diseases; sudden cardiac death; exercise-induced sudden cardiac death; congestive heart failure; chronic obstructive pulmonary disease; and high blood pressure. Irregular heartbeat disorders and diseases include and exercise-induced irregular heartbeat disorders and diseases include, but are not limited to, atrial and ventricular arrhythmia; atrial and ventricular fibrillation; atrial and ventricular tachyarrhythmia; atrial and ventricular tachycardia; catecholaminergic polymorphic ventricular tachycardia (CPVT); and exercise-induced variants thereof. Skeletal muscular disorder and diseases include, but are not limited to, skeletal muscle fatigue, exercise-induced skeletal muscle fatigue, muscular dystrophy, bladder disorders, and incontinence. Cognitive disorders and diseases include, but are not limited to, Alzheimer's Disease, forms of memory loss, and age-dependent memory loss.

The Trustees of Columbia University in the City of New York

Agents for preventing and treating disorders involving modulation of the RyR receptors

A doll in which an illness symptom is created, a treatment is administered and in which the treatment removes the symptom. One symptom is a fever produced by closing a switch which heats the doll's forehead and moving a member near an orifice of the doll's body, the forehead temperature being recognizable by touch and the oral or other indication being detectable by a simulated thermometer. The treatment comprising insertion of a spoon or simulated pill to open the switch and restore the member. Measles (roseola) is simulated by closing a switch to illuminate translucent portions in the body, presenting the appearance of spots. Mumps is simulated by inflating portions of the cheeks and neck, treatment comprising moving a valve member to slowly deflate the portions. Tachycardia is produced by changing the speed of a motor which drives a heartbeat simulating device. Cough-like sound will be produced by recording devices.The doll may also be provided with surgical incisions held closed by VELCRO; multipart arms to simulate fractures; internal balloons which set the fractures when inflated; casts for the limbs; indicator fluids visible at orifices; syringe apertures in the arm and an anaesthic mask, with the doll's eyes arranged to close an injection is given or as mask is fitted in place (a vocal response to anaesthic may also be arranged); or with magnetic misaligned eyeballs which becomes aligned when glasses are fitted in place.

tachycardia/horúčka

Corticotropin releasing factor antagonists

Agents for preventing and treating disorders involving modulation of the RyR receptors

Agents for preventing and treating disorders involving modulation of the RyR receptors

Doll showing sickness, and means for "curing"

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