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CRT-P or CRT-D in Dilated Cardiomyopathy

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The trial goals The ICD-Reality study is an investigator-led, multicenter, prospective, randomized, controlled trial. We aim to determine the effect of CRT-D or CRT-P implantation in non-ischemic cardiomyopathy and heart failure patients. The reason why we initiated this trial is the lack of

Perioperative Analgesic Efficiency of Quadratus Lumborum Block vs Epidural in Radical Cystectomy

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1. Background and rationale: Bladder cancer is the ninth most common cancer in the world while being considerably common in both developed and developing countries. Bladder cancer is the most common malignancy among Egyptian males and it had been previously attributed to Schistosoma infection, a

Short-term Clinical Study of CN128 in Thalassemia Patients

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1. Primary objectives: - To study the tolerance and safety of multiple oral administration of CN128 in patients with thalassemia aged 16 years and above. - To study the pharmacokinetics of CN128 in thalassemia patients aged 16 and above by multiple oral administrations of CN128 2. Design: The study

Clinical Study of CN128 in Thalassemia Patients

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1. Primary objectives: · To determine the maximum tolerated dose (MTD) of CN128 for single oral administration in thalassemia patients aged 16 and above · To study the pharmacokinetics of CN128 in thalassemia patients aged 16 and above 2. Design: The study is designed as a randomized, double-blind,

SBIRT Intervention for Gambling Behaviors

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The Substance Abuse and Mental Health Services Administration (SAMHSA) has made health care and health systems integration one of its main priorities to ensure that behavioral health is consistently incorporated within the context of health care delivery systems. However, this initiative has been

Does Caffeine Enhance Bowel Recovery After Colorectal Surgery?

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Background Postoperative ileus is a frequently occurring surgical complication. It is defined as temporary inhibition of propulsive bowel activity and is manifested by abdominal distention, nausea and vomiting and diet intolerance. It may lead to a prolonged hospital stay, hospital-acquired

Neonatal and Maternal Effects of Buprenorphine and Methadone

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In 2012, 5.4% of pregnant women ages 15 to 44 reported using illicit drugs; however this is lower compared to 11.4% in the non-pregnant population. Illicit drug use is highest in the first trimester (9.0%) and continues to decline as the pregnancy progresses (4.8% 2nd trimester and 2.4% 3rd

Sub-project: Use of Small Implantable ECG Recorder in Pregnant Women With Arrhythmia

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Background Worldwide, the numbers of women who have a pre-existing cardiovascular disease or develop cardiac problems during pregnancy are increasing and, due to the lack of evidenced-based data, this provides challenges for the treating physician. Cardiovascular disease in pregnancy is a complex

Autonomic Nervous Activity During the Systemic Inflammatory Response in Trained and Untrained Healthy Volunteers

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Aim The investigators wish to study the inflammatory response in very well-trained and relatively untrained healthy volunteers using the human endotoxemia model. Also, the investigators wish to study the effect on nicotine on the inflammatory response.. Background 1. Systemic inflammation and the

Effects of Sativex(Registered Trademark) and Oral THC on Attention, Affect, Working Memory, Reversal Learning, Physiology and Brain Activation

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Background: Cannabis sativa contains over sixty cannabinoids, including delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). CBD lacks psychoactivity and may attenuate the subjective effects produced by THC. The ratio of THC:CBD in illicit cannabis in the US is approximately 20:1.

Comparative Study of SR Bupropion for Adolescent Smoking Cessation

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The study will be conducted in Geha Mental Health Center. A total of 80 adolescent non-psychotic smokers will be recruited for this study. A smoker is defined as a cosumer of at least 5 cigarettes daily. A total of 80 patients will be recruited from the adolescent psychiatric wards or the adolescent

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