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Strana 1 od 147 výsledky
Idiopathic retinal degeneration in the dog: differential patterns of [3H]uridine incorporation and HIOMT-like immunoreactivity in surviving photoreceptors.
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Photoreceptor cell pathology was investigated in an 8-yr-old mixed-breed dog which had displayed visual symptoms of 1 month duration. An electroretinogram detected no light-evoked responses. Light and electron microscopic features showed marked thinning and atrophy of the outer both the tapetal and
[Incorporation of 3H-uridine into follicular epithelial cells of degenerating oocytes in the zebrafish, Brachydanio rerio (Ham. Buch.)].
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[Uridine-5-triphosphoric acid in therapeutics. 1. Treatment of neurogenic muscular atrophy].
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Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury.
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Spinal cord injury leads to acute local ischemia, which may contribute to secondary degeneration. Hypoxia stimulates angiogenesis through a cascade of events, involving angiogenesis stimulatory substances, such as vascular endothelial growth factor (VEGF). To test the importance of angiogenesis for
Nogo-A is associated with secondary degeneration of substantia nigra in hypertensive rats with focal cortical infarction.
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We investigated the association of Nogo-A protein, a myelin-associated inhibitor of axon regeneration, with secondary damage of the ipsilateral substantia nigra pars reticulata (SNr) after distal middle cerebral artery occlusion (dMCAO) in adult stroke-prone, renovascular hypertensive rats.
Enterocyte apoptosis and proliferation are increased in microvillous inclusion disease (familial microvillous atrophy).
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Microvillous inclusion disease (MID) is characterized by diffuse villous atrophy without inflammatory changes. While increased apoptosis has been related to mucosal flattening in celiac disease, the role of apoptosis in the pathogenesis of MID is unknown. The aim of this study was to assess the
Lipodystrophia centrifugalis abdominalis infantilis-- immunohistochemical demonstration of an apoptotic process in the degenerating fatty tissue.
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We report a case of lipodystrophia centrifugalis abdominalis infantilis (LCAI) showing apoptosis during the lipoatrophic process by immunohistochemical staining. A 3-year-old boy was seen with a 3-month history of a centrifugally spreading depressed eruption without pain and pruritus on his abdomen.
Autoradiography of 3H-uridine incorporation in the normal early blastocysts of cattle.
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RNA synthesis in morphologically normal early bovine blastocysts collected 7 days after insemination was investigated using fine-structure autoradiography after 3H-uridine incorporation. The level of autoradiographic labelling is proposed as a criterion for assessing metabolic activity in the
Tritiated uridine uptake in the retinal ganglion cell layer of the cat during normal development and after visual cortex ablation.
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The short-term metabolic response of immature retinal ganglion cells to destruction of their target cells in the dorsal lateral geniculate nucleus (dLGN) was assessed in newborn cats. Retrograde degeneration of virtually all dLGN cells was induced by ablation of the 13 contiguous areas of visual
Functional effects of uridine triphosphate on the atrophied soleus muscle of rat after unloading.
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The purposes of the study were to determine the effects of a pyrimidine nucleotide, the uridine triphosphate (UTP), on the contractile and histochemical properties of the soleus (SOL) muscle following disuse atrophy due to hindlimb unloading (HU) hypokinesia. UTP was injected either during the HU
Synthesis and RNA polymerase incorporation of the degenerate ribonucleotide analogue rPTP.
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The synthesis and enzymatic incorporation into RNA of the hydrogen bond degenerate nucleoside analogue 6-(beta-d-ribofuranosyl)-3, 4-dihydro-8H-pyrimido[4,5-c]-[1,2]oxazin-7-one (P) is described. The 5'-triphosphate of this analogue is readily incorporated by T3, T7 and SP6 RNA polymerases into RNA
DNA repair in the degenerating mouse retina.
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In light of different recent results suggesting that the adult mammalian central nervous system can produce new neurons, possibly as an endogenous repair mechanism, we investigated whether neurogenesis occurs in response to photoreceptor degeneration in the rd1 mouse, a model of human-inherited
Purification, cloning, and expression of murine uridine phosphorylase.
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Uridine phosphorylase was purified 10,300-fold from tumors of the murine colorectal adenocarcinoma cell line, Colon-26. Degenerate DNA probes were synthesized corresponding to partial amino acid sequences and used to screen a Colon-26 cDNA library. A cDNA clone of 1327 base pairs that contains a 5'
Metabolic studies on retinal tissue from a donor with a dominantly inherited chorioretinal degeneration resembling sectoral retinitis pigmentosa.
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Protein synthesis, glycosylation, RNA synthesis, and neurotransmitter uptake were monitored using biochemical and autoradiographic techniques following in vitro labeling of retinal tissue from a 79-year-old female with sectoral retinitis pigmentosa (RP). Comparisons were made between degenerate and
Liquid chromatographic method for the determination of uridine in human serum.
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To evaluate uridine levels in humans we developed a very sensitive and specific high-performance liquid chromatographic method for the determination of uridine in serum. We use techniques which are available in a standard analytical laboratory. Chromatographic analysis was carried out on a
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