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9 výsledky
Intracranial malignant peripheral nerve sheath tumor variant: an unusual neurovascular phenotype sarcoma case invading through the petrous bone.
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BACKGROUND
Intracranial malignant peripheral nerve sheath tumor (MPNST) is exceedingly rare. Previously reported cases of intracranial MPNST have been associated with development within a prominent cranial nerve.
METHODS
This is the first report of an MPNST with both nerve sheath and vascular
A retrospective analysis of thalidomide therapy in non-HIV-related Kaposi's sarcoma.
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BACKGROUND
Thalidomide has antiangiogenic and immunomodulatory properties and has recently been used in the management of human malignancies. Several studies have suggested its interest for treating AIDS-related Kaposi's sarcoma.
OBJECTIVE
This study aimed to assess the efficacy and toxicity of
Phase II study of ifosfamide-etoposide-mesna in adults with advanced nonosseous sarcomas.
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Between April 1987 and July 1988, 44 adults with histologically proven, objectively assessable advanced nonosseous sarcomas were treated with 2.5 g of ifosfamide/m2, 100 mg of etoposide/m2, and 2.5 g of mesna/m2 (500 mg/m2 X 5) daily for 3 consecutive days every 4 weeks. This regimen was generally
[A case of facial paralysis caused by granulocytic sarcoma of the external auditory canal].
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Summary A male patients at 11 years of age, was hospitalized for the right ear pain and mouth deviation for five days on August 30, 2016, accompanied by right hypophasis, right ear hearing loss, tinnitus, without otorrhea and vertigo. Patient was diagnosed as acute promyelocytic leukemia in 2008.
[Two cases of primary intracranial malignant lymphoma].
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Two cases of primary intracranial malignant lymphoma are reported. Case 1 was a 65-year-old female who was operated on for a left frontoparietal tumor in 1966 at our hospital, and the tumor was diagnosed as reticulum cell sarcoma histologically. Irradiation was also done. Thereafter, she had had no
A Phase I and pharmacokinetic study of TNP-470 administered weekly to patients with advanced cancer.
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A Phase I study of angiogenesis inhibitor TNP-470 was conducted in patients with advanced cancer. TNP-470 (25-235 mg/m2) was administered i.v. over 4 h once a week to patients who had solid tumors refractory to the best available treatment or with a high risk of recurrence and who had normal renal,
TNP-470: an angiogenesis inhibitor in clinical development for cancer.
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TNP-470, an analogue of fumagillin, has been shown to inhibit angiogenesis in vitro and in vivo. In 1992, TNP-470 entered clinical development for cancer as an anti-angiogenic agent. It is currently in Phase I/II trials in Kaposi's sarcoma, renal cell carcinoma, brain cancer, breast cancer, cervical
Review of the pharmacological properties of toremifene.
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New compounds were synthesized with the aim to develop new anti-estrogenic antitumor drugs. The biological properties of the molecules were screened by (1) estrogen receptor (ER) binding, (2) effect on MCF-7 cells, (3) uterotrophic effect and inhibition of estradiol induced uterotropic effect and
Acute myelogenous leukemia presenting as atypical mastoiditis with facial paralysis.
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Symptomatic otologic involvement by leukemic infiltration is unusual, most often occurring in the already-diagnosed leukemic patient as postauricular mass, acute hemorrhagic otitis media, mastoiditis, cranial neuropathy, vertigo, hearing loss, or leptomeningitis. We think ours is the first reported
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