[Causes of insulin resistance in disorders of glucose tolerance in persons with normal body weight].

A less noticeable decrease in glycemia was observed in patients with disturbed glucose tolerance and normal body mass in the first 20 min of the test with i. v. insulin injection as compared to healthy subjects, which shows resistance to its hypoglycemic effect. At the same time an integral increment of the level of immunoreactive insulin (IRI) over the same period was significantly lower in the patients than that in the control group which was likely to account for resistance to insulin. A decreased content of the blood IRI in the initial period after insulin administration in patients with disturbed glucose tolerance was partially determined by a decrease in the content of the free insulin fraction and an increase in the level of the fraction of blood gamma-globulin bound insulin.