Chemical composition, antimicrobial, modulator and antioxidant activity of essential oil of Dysphania ambrosioides (L.) Mosyakin & Clemants.

The oil presented the α-Terpinene as the major compound with 54.09% presence. Antibacterial activity demonstrated significant MIC against Staphylococcus aureus (256 μg/mL) and moderate against Pseudomonas aeruginosa (512 μg/mL). The modulating effect of antibiotics was significant against P. aeruginosa potentiating the effect of all the antibiotics tested. The IC₅₀ observed for CT LM 23 was clinically relevant (19.3 μg/mL), similar to that obtained for CA INCQS 40006 (25.2 μg/mL). The combined effect with fluconazole also showed significant results, 0.1 and 22.7 μg/mL, for CT LM 23 and CA INCQS 40006, respectively. For CA LM 77 the IC₅₀ was 101.9 μg/mL and for CT INCQS 40042 a value of 53.3 μg/mL. Regarding the modulation, both were considered of clinical relevance, 3.3 and 6.4 μg/mL. OEDA has low antioxidant activity (>1024 μg/mL). Therefore, the popular use against infections was corroborated by this work.