Journal of General Virology 1987-Jul
Inhibitory effect of a protease inhibitor, leupeptin, on the development of influenza pneumonia, mediated by concomitant bacteria.
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The protease inhibitor leupeptin prevented multiple step replication of an influenza virus (A/swine/1976/31, H1N1) mediated by staphylococcal proteases. It also suppressed virus replication and development of fatal pneumonia in mice co-infected with the virus and Staphylococcus aureus.
