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Study of Pathophysiology of Status Epilepticus and Dysimmune Encephalitis

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Prijava / prijava

Epilepsy is one of the most common neurological condition which concerns around 50 million people worldwide. Epilepsy is characterized by a lasting predisposition to generate seizures. Epilepsy can present as heterogenous set of clinical symptoms and is related to extremely varied etiologies. Some

Ambroxol as a Novel Disease Modifying Treatment for Lewy Body Dementia

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Prijava / prijava

The increasing prevalence of dementia is a serious threat to our medical system and our society. About 500,000 Canadians are affected with dementia, and this number will rise to more than 1 million in the next 20 years. Dementia already costs our economy 15 billion dollars per year. While much of

The Effect of Lumbar CSF Drainage on the Neurologic Outcome Improvement in OHCA Underwent TTM

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Prijava / prijava

1. Introduction: Global cerebral ischaemic-reperfusion brain injury following cardiac arrest (CA) can lead to intracranial hypertension and, occasionally, acute brain swelling. Even small increases in brain volume due to edema can result in harmful increases in intracranial pressure due to the

Evaluation of the Effect of Endotracheal Suctioning Applied at Different Head Heights on the Oxygenation of the Brain

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Prijava / prijava

Although the brain is only 2% of body weight,it is the most metabolically active and vital organ of the body.Cells in the brain; they need higher amounts of oxygen and energy than other organs in the body. Therefore, in order to maintain brain functions,rich and continuous blood flow and optimal

Efficacy of Lenses in Abolishing Photoparoxysmal Responses

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Prijava / prijava

1. BACKGROUND Photosensitive epilepsy (PSE) is the most common of reflex epilepsies and represents approximately 10% of all new cases of epilepsy in the age range 7-19 years (Harding & Jeavons, 1994). Photosensitivity is the nuclear feature of PSE, in which seizures are provoked by light stimuli or

A Single Dose Pharmaco-Diagnostic for Peripheral Nerve Continuity After Trauma

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Prijava / prijava

This proposal contains two distinct aims to be investigated in two similar but distinct groups of patients. Aim 1: To examine the mechanistic effect of 4AP on the return of sensorimotor function and EDX sensitivity in the setting of nerve dysfunction from orthopaedic trauma. This aim tests the

Evaluation of Nidus Occlusion After Gamma Knife Radiosurgery of Cerebral Arteriovenous Malformations Using Magnetic Resonance Imaging

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Prijava / prijava

Background Cerebral arteriovenous malformations consist of tangled blood vessels forming a so-called nidus which connects arteries to veins without the interposition of a capillary bed. Due to subsequent structural changes of draining veins within the nidus, patients are at risk of cerebral

SEEG Guided RF-TC v.s. ATL for mTLE With HS

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Prijava / prijava

Nowadays, more and more patients received SEEG implantation for the evaluation of intractable seizures. SEEG is not only a diagnostic method to locate the origin of the epileptic seizures but also a media to treat or to cure this disease. Using radiofrequency thermocoagulation, we are able to

Natural History Study of ATP1A3-related Disease

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Prijava / prijava

Alternating hemiplegia of childhood (AHC) is a rare very disabling neurodevelopmental syndrome caused by mutations in the gene ATP1A3. AHC is characterized by paroxysmal events including attacks of hemiplegia (weakness), dystonia (painful stiffening), oculomotor abnormalities and epileptic seizures.

A Natural History Study of Late Infantile Variant CLN7 And CLN5 Disease

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Prijava / prijava

Neuronal Ceroid Lipofuscinosis (NCL) are comprised of a group of fatal neurodegenerative diseases caused by mutations in an enzyme or protein which results in the accumulation of toxic deposits in the eye, brain, skin, muscle and other cells. CLN7 is a type of NCL caused by homozygous or bi-allelic

Effects of Miglustat Therapy on Infantile Type of Sandhoff and Taysachs Diseases (EMTISTD)

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Prijava / prijava

This study is a case- control, open label clinical trial. Patients are all registered with diagnosis of Sandhoff and Tay sachs, and recruited at children's medical center Tehran-IRAN. Diagnosis is confirmed by enzyme level and genetic tests. Case group receive Miglustat therapy for 1 year and

Co-ultra PEALut Enhances Neuronal Recovery Following Moderate Traumatic Brain Injury

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Prijava / prijava

Study Setting All patients affected by moderate TBI (Glasgow Coma Score 9-13) admitted to the neurosurgical department of the University Hospital of Messina, Italy, will be screened for recruitment. Ethics The institutional review board (IRB) approved the study. Written consent will be obtained from

Optimizing Gestational Weight Gain, Birth Weight and Other Perinatal Outcomes Among Pregnant Women at Risk of Hypertension in Pregnancy

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Prijava / prijava

Background of the Project including Preliminary Observations Hypertensive disorders of pregnancy, including preeclampsia, complicate up to 10% of pregnancies worldwide, constituting one of the greatest causes of fetal growth restriction, preterm birth, low birth weight, perinatal mortality, and

Trial in Low Grade Glioma Patients: Wait or Treat

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Prijava / prijava

non_invasive_aICP_Tumor

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Prijava / prijava

Primary brain tumors in adults are less common than metastatic tumors. The most frequent are glioblastoma multiforme, metastases, anaplastic astrocytoma, meningioma, pituitary tumors and vestibular schwannoma. 70% of the tumors in adults are supratentorial. The most infratentorial tumors are

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