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Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells.

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Prijava / prijava

Lactate is a ubiquitous molecule in cancer. In this exploratory study, our aim was to test the hypothesis that lactate could function as an oncometabolite by evaluating whether lactate exposure modifies the expression of oncogenes, or genes encoding transcription factors, cell division, and cell

Quantification of metabolites in breast cancer patients with different clinical prognosis using HR MAS MR spectroscopy.

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Prijava / prijava

Absolute quantitative measures of breast cancer tissue metabolites can increase our understanding of biological processes. Electronic REference To access In vivo Concentrations (ERETIC) was applied to high resolution magic angle spinning MR spectroscopy (HR MAS MRS) to quantify metabolites in intact

Comparison of HR MAS MR spectroscopic profiles of breast cancer tissue with clinical parameters.

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Prijava / prijava

Breast cancer is the most frequent form of cancer in women and improved diagnostic methods are desirable. Malignant cells have altered metabolism and metabolic mapping might become a tool in cancer diagnostics. High-resolution magic angle spinning (HR MAS) MR spectroscopy of tissue biopsies provides

Effects of tamoxifen on cardiovascular risk factors in postmenopausal women.

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Prijava / prijava

OBJECTIVE To determine the effects of tamoxifen on risk factors for cardiovascular disease in disease-free postmenopausal women. METHODS Double-blind, placebo-controlled, randomized 2-year clinical trial. METHODS University health sciences center. METHODS Clinically postmenopausal women (140) with a

An magnetic resonance-based plasma metabonomic investigation on abnormal Savda in different complicated diseases.

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Prijava / prijava

OBJECTIVE To provide potential evidence for the existence of abnormal Savda, we assessed host metabonomic responses and dynamic changes occurring in various diseases using 1H nuclear magnetic resonance (NMR)-based metabonomics. METHODS Plasma samples taken from patients with complicated diseases

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