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common/tyrosine

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Stran 1 iz 10114 rezultatov

Molecular sorting in polarized and non-polarized cells: common problems, common solutions.

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Prijava / prijava
We have been interested in determining how epithelial cells generate and maintain their characteristically polarized distributions of membrane proteins. Our efforts to date strongly indicate that the polarized transport in MDCK cells may be due to a set of discrete targeting determinants often found

Manage Common Ocular Toxicities From Tyrosine Kinase Inhibitors.

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Prijava / prijava

Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases.

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Prijava / prijava
SMAD proteins mediate signals from receptor serine-threonine kinases (RSKs) of the TGF-beta superfamily. We demonstrate here that HGF and EGF, which signal through RTKs, can also mediate SMAD-dependent reporter gene activation and induce rapid phosphorylation of endogenous SMAD proteins by kinase(s)

Aberrant ALK tyrosine kinase signaling. Different cellular lineages, common oncogenic mechanisms.

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Prijava / prijava
Human HPTP beta, leukocyte common antigen (LCA), and leukocyte common antigen-related molecule (LAR) are transmembrane receptor-like proteins whose cytoplasmic regions contain either one (HPTP beta) or two (LCA and LAR) domains that are homologous to protein tyrosine phosphatases (PTPases). Whereas

KIT mutations are common in testicular seminomas.

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Expression of KIT tyrosine kinase is critical for normal germ cell development and is observed in the majority of seminomas. Activating mutations in KIT are common in gastrointestinal stromal tumors and mastocytosis. In this study we examined the frequency and spectrum of KIT mutations in 54

Tyrosine hydroxylase immunoreactivity is common in the enteric nervous system in teleosts.

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Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of catecholamines and TH immunoreactivity is indicative of cells synthesising either adrenaline/noradrenaline or dopamine. In this study, the distribution of TH immunoreactivity was examined in two distantly related teleost

Tyrosine hydroxylase deficiency in three Greek patients with a common ancestral mutation.

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Prijava / prijava
We present the clinical, biochemical, and molecular findings of three Greek patients with tyrosine hydroxylase (TH) deficiency. All patients presented with a severe clinical phenotype characterized by prominent motor delay, infantile parkinsonism, oculogyric crises, and signs of autonomic

Homology between phenylalanine and tyrosine hydroxylases reveals common structural and functional domains.

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Prijava / prijava
Phenylalanine hydroxylase (PAH) and tyrosine hydroxylase (TYH) are mixed-function oxidases that share many characteristic biochemical and immunological properties. The recent cloning and sequencing of full-length cDNAs for both human PAH and rat TYH allow detailed comparison of their primary

The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase.

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Prijava / prijava
A major protein tyrosine phosphatase (PTPase 1B) has been isolated in essentially homogeneous form from the soluble and particulate fractions of human placenta. Unexpectedly, partial amino acid sequences displayed no homology with the primary structures of the protein Ser/Thr phosphatases deduced

Leukocyte common antigen-related receptor-linked tyrosine phosphatase. Regulation of mRNA expression.

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Prijava / prijava
Receptor-linked tyrosine phosphatases regulate cell growth by dephosphorylating proteins involved in tyrosine kinase signal transduction. Within this gene family, the leukocyte common antigen-related (LAR) gene is of particular interest with respect to the nervous system because it has sequence

Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase.

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Prijava / prijava
It has been proposed on the basis of amino acid sequence homology that the leukocyte common antigen CD45 represents a family of catalytically active, receptor-linked protein tyrosine phosphatases [Charbonneau, H., Tonks, N. K., Walsh, K. A., & Fischer, E. H. (1988) Proc. Natl. Acad. Sci. U.S.A. 85,

A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2).

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Human pancreatic trypsinogens undergo post-translational sulfation on Tyr(154), catalysed by the Golgi-resident enzyme tyrosylprotein sulfotransferase 2. Sequence alignments suggest that the sulfation of Tyr(154) is facilitated by a unique sequence context which is characteristically found in

Adhesion proteins meet receptors: a common theme?

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Prijava / prijava
Receptors tyrosine kinases (RTKs) and cell adhesion molecules (CAMs) present on the cell surface sense the surrounding environment and influence the fate of cells. For a long time, it was believed that these molecules were working independently and that the sole binding of a ligand was enough to

Why tyrosine kinase inhibitor resistance is common in advanced gastrointestinal stromal tumors.

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Prijava / prijava
BACKGROUND Most patients with advanced gastrointestinal stromal tumors (GIST) develop drug resistance to tyrosine kinase inhibitors (TKIs) within two years of starting therapy, whereas most chronic myeloid leukemia (CML) patients in chronic phase still exhibit disease control after a decade on
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