coronary artery disease/debelost

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Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases

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The contents of the text file named SYPA-003_C04US_SeqList_ST25.txt, which was created on Jun. 17, 2015 and is 107 KB in size, are hereby incorporated by reference in their entirety. FIELD OF THE INVENTION The present invention relates to the therapeutic use of guanylate cyclase C (GC-C) agonists as

Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases

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FIELD OF THE INVENTION The present invention relates to the therapeutic use of guanylate cyclase C (GC-C) agonists as for reducing absorption of fat, triglycerides, bile acids and cholesterol. The agonists may be used either alone or in combination with inhibitors of cholesterol biosynthesis in the

Chromosome 11-linked coronary heart disease susceptibility gene CHD1

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TECHNICAL FIELD OF THE INVENTION The present invention relates generally to the field of human genetics. The present invention specifically relates to a human coronary heart disease susceptibility gene (CHD1), some alleles of which are related to susceptibility to coronary heart disease. More

Use of a statin compound as local drug for treating obesity, diabetes, hypertension and hyperlipemia

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FIELD OF THE INVENTION The present invention relates to medicine technology, and more specifically, it relates to a new use of HMG-CoA reductase inhibitor (statins compound) locally used for prevention and treatment of diabetes, obesity, hypertension, hyperlipidemia, artheroslerosis, cardiovascular

Use of a statin compound as topical drug for treating obesity, diabetes, hypertension and hyperlipemia

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This is a U.S. National Phase entry based on PCT/CN2013/001429 filed Nov. 22, 2013, which respectively claiming priority to Chinese patent application 20120512630.8 filed Nov. 23, 2012 and Chinese patent application 201310426327.0 filed Sep. 18, 2013. FIELD OF THE INVENTION The present invention

Method of treating a metabolic disorder induced by obesity in a subject in need thereof by administering MK2/3 inhibitors

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This patent disclosure contains material that is subject to copyright protection. The copyright owner has no objection to the facsimile reproduction by anyone of the patent document or the patent disclosure as it appears in the U.S. Patent and Trademark Office patent file or records, but otherwise

Cyano containing oxamic acids and derivatives as thyroid receptor ligands

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FIELD OF THE INVENTION The present invention relates to novel thyroid receptor ligands and, more particularly, relates to novel cyano containing oxamic acids, and derivatives thereof, which are useful in the treatment of obesity, hyperlipidemia, thyroid disease, hypothyroidism and related disorders

Oxamic acids and derivatives as thyroid receptor ligands

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FIELD OF THE INVENTION The present invention relates to novel thyroid receptor ligands and, more particularly, relates to novel oxamic acids, and derivatives thereof, which are useful in the treatment of obesity, hyperlipidemia, glaucoma, cardiac arrhythmia, skin disorders, thyroid disease,

Oxamic acids and derivatives as thyroid receptor ligands

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Organic compounds

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This application is the National Stage of Application No. PCT/US07/64974 filed Mar. 27, 2007, which claims benefit under 35 U.S.C. .sctn.119(e) of U.S. Provisional Application No. 60/787,104, filed Mar. 29, 2006, the contents of which are incorporated herein by reference in their entirety. The

Biguanide derivative, preparation method thereof, and pharmaceutical composition containing same as an active ingredient

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RELATED APPLICATIONS This application is a 35 U.S.C. .sctn.371 national phase application of PCT/KR2011/000098 (WO 2011/083999), filed on Jan. 6, 2011, entitled "BIGUANIDE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ACTIVE INGREDIENT", which

Biguanide derivative, a preparation method thereof, and a pharmaceutical composition containing the biguanide derivative as an active ingredient

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TECHNICAL FIELD The present invention relates to a biguanide derivative exhibiting excellent effects on activation of 5'-AMP-activated protein kinase (AMPK) and inhibition of cancer cell proliferation in a low dose compared to conventional drugs, a method of preparing the same, and a pharmaceutical

Biguanide derivative, a preparation method thereof, and a pharmaceutical composition containing the biguanide derivative as an active ingredient

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TECHNICAL FIELD The present invention relates to a biguanide derivative exhibiting excellent effects on activation of 5'-AMP-activated protein kinase(AMPK) and inhibition of cancer cell proliferation in a low dose compared to conventional drugs, a method of preparing the same, and a pharmaceutical

Biguanide derivative, preparation method thereof, and pharmaceutical composition containing same as an active ingredient

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TECHNICAL FIELD The present invention relates to a biguanide derivative exhibiting excellent effects on activation of 5'-AMP-activated protein kinase (AMPK) and inhibition of cancer cell proliferation in a low dose compared with conventional drugs, a method of preparing the same, and a

Biguanide derivative, a preparation method thereof and a pharmaceutical composition containing the biguanide derivative as an active ingredient

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RELATED APPLICATIONS This application is a 35 U.S.C. .sctn.371 national phase application of PCT/KR2011/000097 (WO2011/083998), filed on Jan. 6, 2011, entitled "Biguanide Derivative, A Preparation Method Thereof And A Pharmaceutical Composition Containing The Biguanide Derivative As An Active

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