diabetes mellitus type 1/tyrosine

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Inhibitors of protein tyrosine phosphatase

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Prijava / prijava

FIELD OF THE INVENTION The present invention comprises small molecular weight, non-peptidic inhibitors of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM). BACKGROUND OF THE INVENTION The mechanism of

Inhibitors of protein tyrosine phosphatase

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Prijava / prijava

The present invention comprises small molecular weight, non-peptidic inhibitors of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM). BACKGROUND OF THE INVENTION The mechanism of insulin action depends

Modulators of protein tyrosine phosphatases (PTPases)

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Prijava / prijava

FIELD OF THE INVENTION The present invention relates to novel thienopyridines, to methods for their preparation, to compositions comprising the compounds, to the use of these compounds as medicaments and their use in therapy, where such compounds of Formula 1 are pharmacologically useful inhibitors

Protein tyrosine phosphatase inhibitors and methods of use thereof

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Prijava / prijava

FIELD OF THE INVENTION This invention relates to the field of protein tyrosine phosphatase inhibition. BACKGROUND OF THE INVENTION This invention relates to a novel class of phosphonic acid derivatives that are inhibitors of PTP-1B. Reversible protein tyrosine phosphorylation, coordinated by the

Protein tyrosine phosphatase inhibitors and methods of use thereof

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Prijava / prijava

Islet cell antigen 1851

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Prijava / prijava

BACKGROUND OF THE INVENTION Detection of specific autoantigens in prediabetic individuals has been used as a predictive marker to identify, before clinical onset and significant .beta.-cell loss has occurred, those at greater risk of developing IDDM (Gorsuch et al., Lancet 2: 1363-65, 1981;

Islet cell antigen 1851

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Prijava / prijava

BACKGROUND OF THE INVENTION Insulin-dependent diabetes mellitus (IDDM) is a disease resulting from the autoimmune destruction of the insulin-producing .beta.-cells of the pancreas. Studies directed at identifying the autoantigen(s) responsible for .beta.-cell destruction have generated several

Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof

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Prijava / prijava

TECHNICAL FIELD The present disclosure relates to a class of substituted hetero-bicyclic compounds of formula (I), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, hydrates, N-oxides, co-crystals, pharmaceutically acceptable salts and pharmaceutical compositions containing them. The

Pyridotriazines and pyridopyridazines

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FIELD OF THE INVENTION This invention relates to bicyclic heterocycles that inhibit cyclin-dependent kinase or tyrosine kinase enzymes, or both, and as such are useful to treat cell proliferative disorders such as angiogenesis, atherosclerosis, restenosis, and cancer as well as immunological

Polypeptide of protein P140 and DNAs encoding it

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Prijava / prijava

Priority is claimed under 35 USC 1198 to Japanese patent application Hei-5-315806, filed Nov. 24, 1993. SUMMARY The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA

Polypeptide of protein p140 and DNAs encoding it

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Prijava / prijava

SUMMARY The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the said polypeptide; vector comprising the said DNA; host cells transformed with the said vector;

Polypeptide of protein p140 and DNAs encoding it

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Prijava / prijava

SUMMARY The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the said polypeptide; vector derived the said DNA; host cells transformed the said vector; antibody of

Pyrrolo[2,3-d]pyrimidine compounds

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Prijava / prijava

BACKGROUND OF THE INVENTION The present invention relates to pyrrolo[2,3-d]pyrimidine compounds which are inhibitors of protein tyrosine kinases, such as the enzyme Janus Kinase 3 (hereinafter also referred to as JAK3) and as such are useful therapy as immunosuppressive agents for organ transplants,

Polypeptide of protein P140 and DNAS encoding it

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Prijava / prijava

SUMMARY The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the said polypeptide; vector derived the said DNA; host cells transformed the said vector; antibody of

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