A series of 1-piperazinyl-N-phenylacetamide derivatives of 4,5-diphenyl-oxazoles, thiazoles, and imidazoles which are novel adenosine transport inhibitors have been found to provide effective antiischemic protection for CNS and cardiac tissue, particularly neurons. A method of treatment to protect against CNS ischemia, such as that resulting from trauma, stroke, or other ischemic conditions, comprises administration of these novel compounds to an individual in need of such treatment.

Bristol-Myers Squibb Company

Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles

Diphenyl-cyclopropene derivatives, their nontoxic, pharmaceutically acceptable acid addition salts and compositions are kapa opiods useful in the treatment of pain, inflammation, Parkinsonism, dystonia, cerebral ischemia, diuresis, asthma, psoriasis, irritable bowel syndrome and stroke.

Warner-Lambert Company

Diphenyl-cyclopropenes as selective K-agonists

The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: ##STR00001## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer's disease, etc.

diphenyl/možganska kap

Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles

Diphenyl-cyclopropenes as selective K-agonists

Heterocyclic compounds as P2X7 ion channel blockers

Heterocyclic compounds as P2X7 ion channel blockers

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