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Stran 1 iz 16 rezultatov
Tumor retarding (1,2-diphenyl-ethylenediamine)-platinum(II)-complexes
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
BACKGROUND OF THE INVENTION
There are known from German Offenlegungsschrift No. 3405611 antitumor active compounds. Thereby there are described (1,2-diphenyl-ethylenediamine)-platinum (II) complex compounds of the general formula ##STR2## wherein the groups R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are
Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment or prevention of diseases characterized by abnormal cell proliferation
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Prijava / prijava
1. FIELD OF THE INVENTION
The present invention relates to aromatic organic compounds which are specific, potent and safe inhibitors of the Ca.sup.2+-activated potassium channel (Gardos channel) of erythrocytes and/or of mammalian cell proliferation. The compounds can be used to reduce sickle
Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
1. FIELD OF THE INVENTION
The present invention relates to aromatic organic compounds which are specific, potent and safe inhibitors of the Ca.sup.2+ -activated potassium channel (Gardos channel) of erythrocytes and/or of mammalian cell proliferation. The compounds can be used to reduce sickle
Diphenyl disulfide compounds
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Prijava / prijava
FIELD OF THE INVENTION
This invention relates to novel diphenyl disulfide compounds having the activities to inhibit the production of Interleukin-1.beta. (IL-1.beta.) and the release of Tumor Necrosis Factor.alpha. (TNF.alpha.).
BACKGROUND OF THE INVENTION
IL-1.beta. is a protein produced mainly
Heterocyclic diphenyl ethers
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
FIELD OF THE INVENTION
The present invention relates to novel heterocyclic compounds of the general formula (I), derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, pharmaceutically acceptable salts and pharmaceutically acceptable solvates thereof, and pharmaceutically
Kinase inhibitors and their use in cancer therapy
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
This application is a U.S. national phase application under 35 U.S.C. of .sctn. 371 of International Application No. PCT/EP2016/059918, filed May 3, 2016, which claims priority of European Patent No. 15166458.8, filed May 5, 2015, the disclosure of which is hereby incorporated by reference
1,5-diphenyl-penta-1,4-dien-3-one compounds
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
BACKGROUND
Signal Transducer and Activator of Transcription (STAT) proteins are transcription factors that mediate cellular responses to growth factors. These proteins are activated via tyrosine phosphorylation by growth factor receptor-associated tyrosine kinases. Activated STAT proteins promote
Diphenyl derivatives
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
The invention relates to novel diphenyl derivatives, to processes for their preparation and to their use in medicaments.
EP-A-580 550 describes oxamic acid derivatives having cholesterol-lowering properties in mammals. The pharmacological property that is emphasized is the reduction of plasma
Certain substituted diphenyl ureas, as modulators of kinase activity
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Prijava / prijava
Provided herein are certain substituted ureas and related compounds, compositions comprising such compounds, and methods of their use.
Protein kinases, the largest family of human enzymes, encompass well over 500 proteins. Kinases play a key role in angiogenesis. Angiogenesis, the formation of new
Diphenyl-triazole derivatives and their use as anti-gestative, immuno-suppressant and anti-tumoral agents
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Prijava / prijava
OBJECT OF THE PRESENT INVENTION
Objects of the present invention are nitrogen heterocyclic aromatic derivatives and their use as anti-gestative, immunosuppressant and anti-tumoral agents. Object of the present invention is also a procedure for the preparation of nitrogen heterocyclic aromatic
Selective estrogen receptor modulators
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Prijava / prijava
FIELD OF THE INVENTION
This invention pertains to triphenylethylene derivatives, such as, 5-{2-[4-(1,2-Diphenyl-but-1-enyl)-phenyl]-vinyl}-1H-tetrazole, as selective estrogen receptor modulators. This invention also provides methods for treating estrogen stimulated diseases in mammals including, but
Platinum complexes derived from b-silyamines
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
BACKGROUND OF THE INVENTION
There has been a continuing need for new and more effective chemical agents useful in the treatment of cancers in warm blooded animals, especially in human beings. Indeed, the concentrated effort of the National Cancer Institute over the last several years of their
Diphenylhexene composition for use in treating liver carcinoma and psoriasis
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
This application is a continuation of PCT/EP94/02837, filed Aug. 26, 1994, and designating the United States.
The present invention concerns the new chemical compound diphenyl-3-hexene, a process for its production and its use as a therapeutic agent.
Numerous diseases in humans are due to an
Specific salt forms of triphenylethylene derivatives as selective estrogen receptor modulators
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Prijava / prijava
FIELD OF THE INVENTION
This invention pertains to novel salt forms of triphenylethylene derivatives, such as 3-[4(1,2-diphenyl-but-1-enyl)-phenyl]-acrylic acid, as selective estrogen receptor modulators. This invention also provides methods for the treatment and/or prevention of estrogen stimulated
Substituted N-(2-arylamino)aryl sulfonamide-containing combinations
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
The present invention relates: to combinations of: component A: one or more omega-carboxyaryl-substituted diphenyl urea compounds of general formula (I), or a physiologically acceptable salt, solvate, hydrate or stereoisomer thereof; component B: one or more N-(2-arylamino)aryl sulfonamide compounds
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