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Stran 1 iz 227 rezultatov
Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92 kD gelatinase.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
OBJECTIVE
Increased local production of matrix metalloproteinases (MMPs) is a potential mechanism underlying structural protein degradation in abdominal aortic aneurysms (AAA). With an elastase-induced rodent model of AAA, we determined whether pharmacologic treatment with an MMP-inhibiting
Fecal elastase-1 is decreased in villous atrophy regardless of the underlying disease.
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Prijava / prijava
BACKGROUND
Fecal elastase-1 (E1) is a sensitive and reliable test in the assessment of exocrine pancreatic function in cystic fibrosis (CF). In patients with celiac disease (CD), different E1 values have been reported. E1 levels in other malabsorption conditions are unknown. Therefore, the aim of
Gene transfer of the serine elastase inhibitor elafin protects against vein graft degeneration.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
BACKGROUND
Leukocyte infiltration and serine elastase activity lead to smooth muscle cell proliferation in association with posttransplant coronary arteriopathy and may also be involved in vein graft neointimal formation. A number of therapies have targeted cellular proliferation, but the inhibition
Acute mechanical forces cause deterioration in lung structure and function in elastase-induced emphysema.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
The relation between the progression of chronic obstructive pulmonary disease (COPD) and exacerbations is unclear. Currently, no animal model of acute exacerbation of COPD (AECOPD) exists. The objectives of this study were to evaluate the effects of mechanical forces induced by deep inspirations
Systemic bone loss, impaired osteogenic activity and type I muscle fiber atrophy in mice with elastase-induced pulmonary emphysema: Establishment of a COPD-related osteoporosis mouse model.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Although it is suggested that chronic obstructive pulmonary disease (COPD) and bone are related, almost all of the pathological mechanisms of COPD-related osteoporosis remain unknown. There is a mouse model showing a deterioration of bone quality after cigarette smoke exposure; however, in smoking
Peritendinous elastase treatment induces tendon degeneration in rats: A potential model of tendinopathy in vivo.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
The purpose of this study was to investigate the role of elastase on tendinopathy, as well as to evaluate the potential for peritendinous injections of elastase into rats to cause tendinopathy. We first investigated the expression of elastase in the tendons of patients with tendinopathy, and then
Lung volume reduction surgery does not improve diaphragmatic contractile properties or atrophy in hamsters with elastase-induced emphysema.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
It is claimed that lung volume reduction surgery (LVRS) improves inspiratory muscle function. As diaphragm structure and function are not directly appraisable in patients, we studied the effects of LVRS on the diaphragm in vitro contractile properties and morphology in hamsters with elastase-induced
Annexin V decreases PS-mediated macrophage efferocytosis and deteriorates elastase-induced pulmonary emphysema in mice.
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Prijava / prijava
Efferocytosis is believed to be a key regulator for lung inflammation in chronic obstructive pulmonary disease. In this study we pharmacologically inhibited efferocytosis with annexin V and attempted to determine its impact on the progression of pulmonary emphysema in mouse. We first demonstrated in
[The effects of glucagon and elastase on the trophism of the vascular wall in experimental atheromatous degeneration in chickens].
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
The activation of the atypical PKC zeta in light-induced retinal degeneration and its involvement in L-DNase II control.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Light-induced retinal degeneration is characterized by photoreceptor cell death. Many studies showed that photoreceptor demise is caspase-independent. In our laboratory we showed that leucocyte elastase inhibitor/LEI-derived DNase II (LEI/L-DNase II), a caspase-independent apoptotic pathway, is
Aneurysm induced by periarterial application of elastase heals spontaneously.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
BACKGROUND
The pathogenesis of aortic aneurysms remains largely unknown, despite aneurysmal rupture being an increasingly common catastrophe.
METHODS
This study was designed to elucidate the mechanism of arterial dilatation histologically and electron microscopically, utilising a new animal model.
Morphological and biochemical features of elastase-induced emphysema in strain A/J mice.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Elastase-induced animal models of pulmonary emphysema are potentially useful to study the physiological, anatomical, and biochemical injuries associated with emphysema. After the endotracheal instillation of porcine pancreatic elastase (0.15 or 0.30 mg elastase per 100 g body weight) into strain A/J
Neutrophil elastase, von Willebrand factor, soluble thrombomodulin and percutaneous oxygen in peripheral atherosclerosis.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
OBJECTIVE
To test the hypothesis that endothelial cell damage and hypoxia are related to the activity of neutrophil elastase in patients with peripheral atherosclerosis.
METHODS
A cross-sectional serological study in a tertiary referral, University Hospital.
METHODS
Venous blood was obtained from 22
Biaxial strain properties of elastase-digested porcine aortic valves.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
OBJECTIVE
Previous studies have suggested that elastin in porcine aortic valve cusps is responsible for restoring collagen fibers to their original configuration between loading-unloading cycles.
METHODS
Biaxial loading tests were performed on intact aortic valves before and after elastase treatment
Degradation of elastic fiber and elevated elastase expression in long head of biceps tendinopathy.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Tendinopathy of the long head of the biceps (TLHB) involves various types of extracellular matrix degeneration, but previous studies have not evaluated elastic fibers. The purpose of this study was to investigate elastic fiber distribution in long head of the biceps (LHB). The TLHB tendons of 16
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