fibrosarcoma/nikotin

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Effects of chronic tobacco smoke exposure on immune responses in aged mice.

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Prijava / prijava

Balb/c mice were exposed to fresh smoke, equivalent to 30 high-tar filtered cigarettes/day, for 83 wk or less. After groups of mice were subjected to 56, 64, 72, and 80 wk of tobacco smoke (TS) exposure, serum antibody responses to both T-dependent and T-independent antigens, numbers of

6-hydroxy-nicotine-inducible multilevel transgene control in mammalian cells.

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Prijava / prijava

The precise control of transgene expression is essential for biopharmaceutical manufacturing, gene therapy and tissue engineering. We have designed a novel conditional transcription technology, which enables reversible induction, repression and adjustment of desired transgene expression using the

Experimental studies on betel nut and tobacco carcinogenicity.

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Prijava / prijava

Sun-dried Mangalore betel nut extracts in water and in DMSO, and sun-cured Vadakkan tobacco extract in DMSO, were tested for their carcinogenic potency. Inbred Swiss and C17 mice and golden hamsters were used for the experiments. Control animals treated with either DMSO or water did not show any

Maternal use of illicit drugs, tobacco or alcohol and the risk of childhood cancer before 6 years of age.

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Prijava / prijava

Previous studies provide conflicting evidence of a link between maternal substance use and risk of childhood cancer.We analyzed a cohort of 785,438 newborns in Quebec (2006-2016). We identified infants whose mothers had problematic illicit drug, tobacco, or

Effect of cigarette tar upon tissue culture cells. Neoplastic transformation of hamster lung cells by tobacco tar in tissue culture.

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Prijava / prijava

Hamster lung fibroblastic cells were transformed into malignant cells in vitro by exposure to crude cigarette tar for 3 hours. Primary injuries of cells were observed between 2 and 48 hours after the treatment. Tar-treated cells showed nuclear pyknosis, cell necrosis, and enlarged, vacuolated

NTP Toxicology and Carcinogenesis Studies of 2,6-Xylidine (2,6-Dimethylaniline) (CAS No. 87-62-7) in Charles River CD Rats (Feed Studies).

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Prijava / prijava

2,6-Xylidine is a chemical intermediate used principally in the production of dyes. It is also a component of tobacco smoke, a degradation product of aniline-based pesticides, and a metabolite of certain drugs, particularly the xylide group of local anesthetics. The National Toxicology Program (NTP)

Modulation of 5-ALA-induced PpIX xenofluorescence intensities of a murine tumour and non-tumour tissue cultivated on the chorio-allantoic membrane.

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Prijava / prijava

Exogenous administration of 5-aminolaevulinic acid (5-ALA), an early precursor in haem synthesis, induces accumulation of endogenous photo-active porphyrins, particularly protoporphyrin IX (PpIX). Modulation of 5-ALA-induced PpIX-xenofluorescence intensities of a murine tumour and normal

Development of novel therapeutic strategies for lung cancer: targeting the cholinergic system.

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Prijava / prijava

One of the earliest descriptions of non-neuronal ACh synthesis was by Morris who reported that ACh was synthesized in the placenta [1]; furthermore, Falugi et al. showed the presence of AChE in human fibrosarcoma cells [2]. Afterward, the expression of ACh, AChE, and cholinergic receptors in

Malignant transformation of mouse cells by cigarette smoke condensate.

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Prijava / prijava

A low-nicotine cigarette smoke condensate, 12 fractions of the condensate, and a reconstituted sample were tested for their ability to induce transformation in the mouse cell line 3H/10T-1/2 CL-8. This cell line is noted for its remarkable low spontaneous rate of transformation. Both the crude

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