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4 rezultatov
Geraniol and beta-ionone inhibit proliferation, cell cycle progression, and cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells independent of effects on HMG-CoA reductase activity.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase catalyzes the formation of mevalonate, a precursor of cholesterol that is also required for cell proliferation. Mevalonate depletion results in a G1 phase cell cycle arrest that is mediated in part by impaired activity of cyclin-dependent
The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Bisphosphonates are well established in the management of breast-cancer-induced bone disease. Recent studies have suggested that these compounds are effective in preventing the development of bone metastases. However, it is unclear whether this reflects an indirect effect via an inhibition of bone
Use of synthetic isoprenoids to target protein prenylation and Rho GTPases in breast cancer invasion.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Dysregulation of Ras and Rho family small GTPases drives the invasion and metastasis of multiple cancers. For their biological functions, these GTPases require proper subcellular localization to cellular membranes, which is regulated by a series of post-translational modifications that result in
The effect of some natural antioxidants against cisplatin-induced neurotoxicity in rats: behavioral testing
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Background: Cisplatin (CP) is a common antineoplastic agent widely used to treat a broad spectrum of cancers. However, its usage for cancer treatment was restricted due to various side effects such as neurotoxicity, nephrotoxicity,
Najbolj popolna baza zdravilnih zelišč, podprta z znanostjo
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