glutamate decarboxylase/gluhost

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Changes in neuronal activity and gene expression in guinea-pig auditory brainstem after unilateral partial hearing loss.

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Prijava / prijava

Spontaneous neural hyperactivity in the central auditory pathway is often associated with deafness, the most common form of which is partial hearing loss. We quantified both peripheral hearing loss and spontaneous activity in single neurons of the contralateral inferior colliculus in a guinea-pig

Consequences of noise- or styrene-induced cochlear damages on glutamate decarboxylase levels in the rat inferior colliculus.

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Prijava / prijava

Both noise and styrene can injure the cochlea, resulting in a reduction of incoming inputs from the cochlea to the central nervous system. In addition, styrene is known to have neurotoxic properties at high doses. The loss of inputs caused by noise has been shown to be compensated by a new

Modulation of gene expression in guinea pig paraflocculus after induction of hearing loss.

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Prijava / prijava

Hearing loss often results in plastic changes in the central auditory pathways, which may be involved in the generation of tinnitus, a phantom auditory sensation. However, although animal studies have consistently shown increased neural activity in auditory structures after hearing loss, tinnitus

Tinnitus Correlates with Downregulation of Cortical Glutamate Decarboxylase 65 Expression but not Auditory Cortical Map Reorganization.

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Prijava / prijava

Hearing loss is the biggest risk factor for tinnitus and hearing loss-related pathological changes in the auditory pathway have been hypothesized as the mechanism underlying tinnitus. However, due to the comorbidity of tinnitus and hearing loss, it has been difficult to differentiate between neural

Autoimmune IDDM in a sporadic MELAS patient with mitochondrial tRNA(Leu(UUR)) mutation.

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Prijava / prijava

We report a 28-year-old young male with MELAS syndrome (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes) presenting with two previous episodes of stroke-like manifestation, lactic acidosis and mitochondrial cardiomyopathy. He was also affected with insulin-dependent

Physiology of the aged Fischer 344 rat inferior colliculus: responses to contralateral monaural stimuli.

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Prijava / prijava

1. Presbycusis, age-related hearing loss, is an ever increasing problem in our aging society. It involves changes in both the peripheral and central portions of the auditory system. The inferior colliculus (IC) has been shown to display age-related changes including decreased gamma-aminobutryic acid

Acoustic trauma evokes hyperactivity and changes in gene expression in guinea-pig auditory brainstem.

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Prijava / prijava

Hearing loss from acoustic trauma is a risk factor for tinnitus. Animal models using acoustic trauma have demonstrated hyperactivity in central auditory pathways, which has been suggested as a substrate for tinnitus. We used a guinea-pig model of unilateral acoustic trauma. Within the same animals,

Noise exposure alters MMP9 and brevican expression in the rat primary auditory cortex.

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Prijava / prijava

This study aimed to investigate the changes in molecules related to perineuronal nets (PNNs) and synaptic transporters in the primary auditory cortices of rats with noise-induced hearing loss. Female Sprague-Dawley rats at postnatal day 7 were divided into the noise and control groups.

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