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Stran 1 iz 55 rezultatov
No-releasing guanidine-coxib anti-cancer agents
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Prijava / prijava
FIELD
The present invention generally relates to NO-releasing coxib compounds, pharmaceutical compositions comprising the compounds, methods useful for treating a subject by administering a therapeutically effective amount of the compounds, and methods for making the compounds. More specifically,
Guanidine compounds and use thereof
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Prijava / prijava
TECHNICAL FIELD
The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof more specifically, the present invention relates to a pharmaceutical composition for preventing or treating a disease associated with OXPHOS,
Guanidine substituted imidazo[4,5-c] ring compounds
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Prijava / prijava
BACKGROUND
Some drug compounds act by stimulating certain key aspects of the immune system, as well as by suppressing certain other aspects (e.g., U.S. Pat. Nos. 6,039,969 and 6,200,592). These compounds are sometimes referred to as immune response modifiers (IRMs). Some IRM compounds are useful for
Guanidine substituted imidazo[4,5-c] ring compounds
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
BACKGROUND
Some drug compounds act by stimulating certain key aspects of the immune system, as well as by suppressing certain other aspects (e.g., U.S. Pat. Nos. 6,039,969 and 6,200,592). These compounds are sometimes referred to as immune response modifiers (IRMs). Some IRM compounds are useful for
Imidazo[4,5-c] ring compounds containing substituted guanidine groups
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
BACKGROUND
Some drug compounds act by stimulating certain key aspects of the immune system, as well as by suppressing certain other aspects (e.g., U.S. Pat. Nos. 6,039,969 and 6,200,592). These compounds are sometimes referred to as immune response modifiers (IRMs). Some IRM compounds are useful for
Polymorphs of N-(6-(4-chlorophenoxy)hexyl)-N'-cyano-N''-(4-pyridyl)guanidine, and preparation thereof and use thereof
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Prijava / prijava
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is the U.S. National Stage entry of PCT/CN2011/081238, filed Oct. 25, 2011, which claims benefit of China Patent Application No. 201010519331.8, filed Oct. 26, 2010, the disclosures of each are herein incorporated by reference.
FIELD OF THE
Modified hydroxypolymer conjugates with killing effect on tumor cells
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Prijava / prijava
TECHNICAL FIELD OF INVENTION
The present invention is related to a modified hydroxypolymer conjugate, particularly a guanidine-dextran conjugate having a tumor killing effect, and a method for preparation of said conjugates as well as its use.
BACKGROUND OF INVENTION
Guanidine compounds have many
Salts of guanidine derivatives and pharmaceutical preparations consisting thereof
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Prijava / prijava
FIELD OF THE INVENTION
The invention relates to new salts of guanidine derivatives and pharmaceutical preparations containing these as the active ingredient, as well as their preparation.
BACKGROUND OF THE INVENTION
WO 97/45401, incorporated by reference herein, discloses guanidine derivatives of
Phenyl-guanidine derivatives
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Prijava / prijava
The present invention relates to new series of phenyl-guanidine derivatives for the inhibition of Rac1 which blocks its interaction with guanosine exchange factors (GEFs) belonging to the DBL family as agents for the treatment of aggressive and/or resistant tumours, as well as to processes for their
Saturated acyl guanidine for inhibition of F.sub.1F.sub.0-ATPase
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Prijava / prijava
FIELD OF THE INVENTION
The invention provides inhibitors of F.sub.1F.sub.0-ATPases (e.g., mitochondrial F.sub.1F.sub.0-ATPases) and their therapeutic use. In particular, the invention provides saturated acyl guanidine compounds that inhibit F.sub.1F.sub.0-ATPase, and methods of using saturated acyl
Pyrazolyl guanidine F.sub.1F.sub.0-ATPase inhibitors and therapeutic uses thereof
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Prijava / prijava
FIELD OF THE INVENTION
The invention provides inhibitors of F.sub.1F.sub.0-ATPases (e.g., mitochondrial F.sub.1F.sub.0-ATPases) and their therapeutic use. In particular, the invention provides pyrazolyl guanidine compounds that inhibit F.sub.1F.sub.0-ATPase, and methods of using pyrazolyl guanidine
Pyrazolyl guanidine F.sub.1F.sub.0-ATPase inhibitors and therapeutic uses thereof
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
FIELD OF THE INVENTION
The invention provides inhibitors of F.sub.1F.sub.0-ATPases (e.g., mitochondrial F.sub.1F.sub.0-ATPases) and their therapeutic use. In particular, the invention provides pyrazolyl guanidine compounds that inhibit F.sub.1F.sub.0-ATPase, and methods of using pyrazolyl guanidine
Alkylpyrazolyl guanidine F.sub.1F.sub.0-ATPase inhibitors and therapeutic uses thereof
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Prijava / prijava
FIELD OF THE INVENTION
The invention provides inhibitors of F.sub.1F.sub.0-ATPases (e.g., mitochondrial F.sub.1F.sub.0-ATPases) and their therapeutic use. In particular, the invention provides pyrazolyl guanidine compounds that inhibit F.sub.1F.sub.0-ATPase, and methods of using pyrazolyl guanidine
Pyrazolyl guanidine F.sub.1F.sub.0-atpase inhibitors and therapeutic uses thereof
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
FIELD OF THE INVENTION
The invention provides inhibitors of F.sub.1F.sub.0-ATPases (e.g., mitochondrial F.sub.1F.sub.0-ATPases) and their therapeutic use. In particular, the invention provides pyrazolyl guanidine compounds that inhibit F.sub.1F.sub.0-ATPase, and methods of using pyrazolyl guanidine
Cycloalkyl guanidine F.sub.1F.sub.0-ATPase inhibitors and therapeutic uses thereof
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Prijava / prijava
FIELD OF THE INVENTION
The invention provides inhibitors of F.sub.1F.sub.0-ATPases (e.g., mitochondrial F.sub.1F.sub.0-ATPases) and their therapeutic use. In particular, the invention provides cycloalkyl guanidine compounds that inhibit F.sub.1F.sub.0-ATPase, and methods of using cyclalkyl guanidine
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