9 rezultatov
TECHNICAL FIELD
This invention relates to novel N-benzenesulfonyl L-proline compounds. These compounds are useful as antagonists of bradykinin, and are thus useful in the treatment of inflammation, asthma, allergic rhinitis, pain or the like in mammalian, especially humans. The present invention
SUMMARY OF THE INVENTION
The compounds of the present invention are antagonists of the VLA-4 integrin ("very late antigen-4"; CD49d/CD29; or .alpha..sub.4.beta..sub.1), the .alpha..sub.4.beta..sub.7 integrin (LPAM-1 and .alpha..sub.4.beta..sub.p), and/or the .alpha..sub.9.beta..sub.1 integrin, and
The invention relates to a method of cosmetic treatment which makes it possible in particular to prevent or reduce the intolerance reactions of the skin, by virtue of the use of a cosmetic composition comprising a particular peptide as additive.
The use of such a peptide as additive in a cosmetic
This invention relates to novel benzoquinone derivatives having inhibitory activities of protocollagen proline hydroxylase, collagen biosynthesis and 5-lipoxygenase.
Protocollagen proline hydroxylase is an enzyme which specifically hydroxylates the proline residues of the protocollagen synthesized
This invention relates to novel benzoquinone derivatives having inhibitory activities of protocollagenproline hydroxylase, collagen biosynthesis and 5-lipoxygenase.
Protocollagen proline hydroxylase is an enzyme which specifically hydroxylates the proline residues of the protocollagen synthesized by
This invention relates to novel benzoquinone derivatives having inhibitory activities of protocollagenproline hydroxylase, collagen biosynthesis and 5-lipoxygenase.
Protocollagen proline hydroxylase is an enzyme which specifically hydroxylates the proline residues of the protocollagen synthesized by
This invention relates to novel benzoquinone derivatives having inhibitory activities of protocollagen proline hydroxylase, collagen biosynthesis and 5-lipoxygenase.
Protocollagen proline hydroxylase is an enzyme which specifically hydroxylates the proline residues of the protocollagen synthesized
This invention relates to novel benzoquinone derivatives having inhibitory activities of protocollagen-proline hydroxylase, collagen biosynthesis and 5-lipoxygenase.
Protocollagen proline hydroxylase is an enzyme which specifically hydroxylates the proline residues of the protocollagen synthesized
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a novel hexapeptide and a pharmaceutically acceptable salt thereof. The hexapeptide has an increasing vascular permeability suppression action, an anti-edematous action, an anti-inflammatory action, an vascular