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immunostimulator/infarkt

Povezava se shrani v odložišče
ČlankiKliničnih preskušanjPatenti
7 rezultatov

Thalidomide attenuates the development of fibrosis during post-infarction myocardial remodelling in rats.

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
BACKGROUND Inflammation plays a pathogenic role in the development of heart failure (HF). The aim of this study was to examine the effect of treatment with the immunomodulating drug thalidomide in a rat model for post-myocardial infarction (MI) HF. METHODS Rats were subjected to MI by left coronary

An association study in essential hypertension using functional polymorphisms in lymphotoxin-alpha gene.

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
BACKGROUND Lymphotoxin-alpha (LTA), a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The substance LTA mediates a wide variety of inflammatory, immunostimulatory, and antiviral responses. In 2002, LTA was identified as a major risk factor for myocardial infarction
Post-ischemic inflammation plays an important role in the progression of ischemia/reperfusion injuries. Prothymosin-α (ProT) can protect cells from necrotic death following ischemia; however, its immunostimulatory actions may counteract the neuroprotective effect. We proposed that ProTΔNLS,

Phase II trial of systemic recombinant interleukin-2 in the treatment of refractory nasopharyngeal carcinoma.

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Prijava / prijava
BACKGROUND Interleukin-2 (IL-2) is a cytokine produced by activated T cells, which has shown powerful immunostimulatory and antineoplastic properties. Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus-associated cancer with abundant lymphocyte infiltration histologically. The activity of IL-2

[Role of the infection and inflammation in atherosclerosis development (literature review)].

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
ecent researches have shown that the atherosclerosis is a chronic inflammatory disease. In particular, chronic inflammation plays a key role in coronary artery plaque instability and subsequent occlusive thrombosis. Inflammatory and immune mechanisms, employing monocytes, innate receptors, cytokines
OBJECTIVE A phase I trial was undertaken because interleukin-1 alpha (IL-1 alpha) possesses antiproliferative, immunostimulatory, antiinfection, myeloprotective, and myelorestorative properties that could be beneficial in cancer treatment. METHODS In this phase I trial, IL-1 alpha was administered
Indoleamine 2,3-dioxygenase 1 (Ido1) is a rate-limiting enzyme that catalizes the degradation of tryptophan along the kynurenine pathway. Here, we show that Ido1 activity sustains an immunostimulatory potential through inhibition of interleukin (Il)10. In atherosclerosis, Ido1-dependent inhibition
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