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Lasting treatment effects in a postmarketing surveillance study of prolonged-release melatonin.

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Prijava / prijava

Surveillance studies are useful to evaluate how a new medicinal product performs in everyday treatment and how the patient who takes it feels and functions, thereby determining the benefit/risk ratio of the drug under real-life conditions. Prolonged-release melatonin (PRM; Circadin) was approved in

[Melatonin secretion in intracranial tumor].

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Prijava / prijava

The secretion of melatonin (MLT) was examined in 6 ICT patients, 2 men and 4 women, who showed marked midline shift of CT scan findings with intracranial hypertension signs (headache, nausea, vomiting). Their ages ranged from 22 to 40 years. The controls, 6 healthy men and 4 healthy women

Melatonin Immunoreactivity in Malignant Small Intestinal Neuroendocrine Tumours.

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Prijava / prijava

OBJECTIVE Small intestinal neuroendocrine tumours (SI-NETs) are derived from enterochromaffin cells. After demonstrating melatonin in enterochromaffin cells, we hypothesized that SI-NETs may express and secrete melatonin, which may have an impact on clinical factors and treatment

Cognitive performance following premature awakening from zolpidem or melatonin induced daytime sleep.

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Prijava / prijava

BACKGROUND The hypnotic zolpidem and the hormone melatonin were evaluated and directly compared for their effects on performance when subjects sleeping under their influence were prematurely awakened from daytime sleep. METHODS Non-sleep deprived volunteers (eight men and five women) received single

Somatostatin, retinoids, melatonin, vitamin D, bromocriptine, and cyclophosphamide in advanced non-small-cell lung cancer patients with low performance status.

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Prijava / prijava

BACKGROUND The prognosis of low performance status (PS) patients with advanced non-small-cell-lung cancer (NSCLC) is dismal. In these patients, we have determined the survival, clinical benefits, and toxicity of a multidrug regimen, based on cyclophosphamide and biotherapeutical

Oral Melatonin Versus Midazolam as Premedication for Intravenous Sedation in Pediatric Dental Patients.

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Prijava / prijava

This study aimed to evaluate the effect of oral melatonin and oral midazolam as premedication for intravenous (IV) sedation of pediatric dental patients.This crossover, double-blind randomized clinical trial was conducted on 23 uncooperative 2-6-year-olds

Comparison of the effects of preoperative melatonin or vitamin C administration on postoperative analgesia.

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Prijava / prijava

The analgesic benefit of melatonin and vitamin C as primary or adjuvant agents has been reported in various studies; however, their analgesiceffects in the treatment of postoperative pain remain unclear. Thus, we aimed to evaluate the effect of preoperative single dose of oral melatonin and vitamin

Effect of Melatonin on Postoperative Pain and Perioperative Opioid Use: A Meta-analysis and Trial Sequential Analysis

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Prijava / prijava

Objectives: We performed the meta-analysis in order to assess the effect of melatonin on postoperative pain and perioperative opioid consumption. Methods: We systematically

Sleep quality, morningness-eveningness preference, mood profile, and levels of serum melatonin in migraine patients: a case-control study.

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Prijava / prijava

The melatonin as the pineal gland's secretory product is implicated in the pathophysiology of migraine. Melatonin has critical functions in human physiology, and research underscores the importance of melatonin in circadian rhythm, sleep, and mood regulation. Clinical observations have indicated

Melatonin as adjuvant cancer care with and without chemotherapy: a systematic review and meta-analysis of randomized trials.

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Prijava / prijava

BACKGROUND Melatonin (MLT) is known to possess potent antioxidant, antiproliferative, immune-modulating, and hormone-modulating properties. Clinical evidence suggests that MLT may have a possible role in the treatment of cancer. The authors systematically reviewed the effects of MLT in conjunction

Effectiveness and tolerability of melatonin and zolpidem for the alleviation of jet lag.

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BACKGROUND The aim of this study was to compare the effectiveness and tolerability of a chronobiotic (melatonin) with a hypnotic (zolpidem) and the combination of both substances to alleviate jet lag symptoms associated with eastward travel. METHODS This double-blind, randomized, placebo-controlled

Somatostatin, retinoids, melatonin, vitamin D, bromocriptine, and cyclophosphamide in chemotherapy-pretreated patients with advanced lung adenocarcinoma and low performance status.

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Prijava / prijava

BACKGROUND We previously reported on an improvement in survival and quality of life in chemotherapy-naïve patients with advanced non-small-cell lung cancer and low performance status (PS) treated with a combination of biotherapeutical agents and cyclophosphamide. In this study, we assessed the

The Safety of Melatonin in Humans.

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Prijava / prijava

Exogenous melatonin has been investigated as treatment for a number of medical and surgical diseases, demonstrating encouraging results. The aim of this review was to present and evaluate the literature concerning the possible adverse effects and safety of exogenous melatonin in humans. Furthermore,

Research on complementary/alternative medicine for patients with breast cancer: a review of the biomedical literature.

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Prijava / prijava

OBJECTIVE This article reviews English-language articles published in the biomedical literature from 1980 to 1997 that reported results of clinical research on complementary and alternative medical treatments (CAM) of interest to patients with breast cancer. METHODS We searched 12 electronic

Ice Pick Headache.

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Prijava / prijava

Ice pick headache, also called idiopathic or primary stabbing headache, is a unique headache type associated with ultra-brief stabs of pain, most commonly in the frontal or temporal area. It occurs predominantly in women and is estimated to affect 2-35% of the population. Unlike other headache types

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