neoplasm metastasis/tyrosine

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Phosphatase associated with metastasis

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BACKGROUND OF THE INVENTION 1. Field of the Invention The invention relates to the field of cancer diagnostics and therapeutics. In particular it relates to a gene which appears to be significantly associated with the progression of cancer to more advanced stages, including metastasis. 2. Background

Treatment of metastatic disease

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FIELD OF THE INVENTION The present invention relates to diagnosis and treatment of metastatic disease. More particularly, this invention relates to the use of an epithelial cell tyrosine kinase that is overexpressed in metastatic tumor cells as the target for the diagnosis and treatment of

Method for activating T cell protein tyrosine phosphatase for therapeutic applications

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FIELD OF THE INVENTION This invention relates to a method for activation of T cell protein tyrosine phosphatase (TCPTP) and a method for inhibiting tyrosine kinase signalling in an individual. Further, the invention concerns a method for preventing or treating a disease or disorder in an individual,

Tyrosine alkoxyguanidines as integrin inhibitors

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FIELD OF THE INVENTION The present invention relates to novel tyrosine alkoxyguanidine compounds that are inhibitors of alpha V (.alpha.v) integrins, for example .alpha.v.beta.3 and .alpha.v.beta.5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions

Modulation of pleiotrophin signaling by receptor-type protein tyrosine phosphatase beta/zeta

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BACKGROUND OF THE INVENTION Pleiotrophin (PTN) is a platelet-derived growth factor-inducible heparin-binding growth and differentiation factor that signals diverse phenotypes in normal and deregulated cellular growth and differentiation. See Milner, et al., (1989) Biochem. Biophys. Res. Commun. 165,

Keratinocyte growth factor receptor--tyrosine specific inhibitors for the prevention of cancer metastatis

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BACKGROUND Current cancer chemotherapy or radiation treatment is designed to kill all rapidly growing cells; thus, resulting in a very high incidence of adverse side effects and toxicity. Further, very few cancer treatments are specifically designed to prevent the metastatic development and

Over-expression and mutation of a tyrosine kinase receptor FGFR4 in tumors

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FIELD This disclosure relates to tyrosine kinases, particularly receptor tyrosine kinases with one or more variants. Further, it relates to methods of using these molecules in screens and analyses, including diagnoses, prognoses, and systems for identification and/or selection of pharmaceutical

Inhibition of cell motility, angiogenesis, and metastasis

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FIELD OF THE INVENTION The present invention in general relates to a method of inhibiting cell motility and angiogenesis and treating various diseases in a mammal, and particularly to a method of inhibiting cell motility and angiogenesis induced by the hepatocyte growth factor (HGF). The present

Shp-2 inhibitors and pharmaceutical compositions comprising them

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The present invention relates to small molecule protein tyrosine phosphatase inhibitors, especially Shp-2 inhibitors, of formulae (I) and/or (II), and to pharmaceutical compositions comprising them. The invention is also directed to the use of said compounds for the treatment of phosphatase-mediated

Combination therapy with anti-HLA-DR antibodies and kinase inhibitors in hematopoietic cancers

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SEQUENCE LISTING The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Mar. 27, 2017, is named IMM367US1_SL.txt and is 7,866 bytes in size. FIELD OF THE

Gene therapy for inhibition of angiogenesis

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FIELD OF THE INVENTION The present invention relates to methods of gene therapy for inhibiting angiogenesis associated with tumor growth, inflammation, psoriasis, rheumatoid arthritis, hemangiomas, diabetic retinopathy, angiofibromas, and macular degeneration. This invention also relates to animal

Indeno[1,2-c]-, naphtho[1,2-c]- and benzo[6,7]cyclohepta[1,2-c]pyrazole derivatives

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BACKGROUND OF THE INVENTION Protein tyrosine kinases (PTKs) comprise a large and diverse class of proteins having enzymatic activity. The PTKs play an important role in the control of cell growth and differentiation (for review, see Schlessinger & Ullhrich, 1992, Neuron 9:383-391). For example,

Pharmaceutical compositions comprising porphyrins and some novel porphyrin derivatives

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FIELD OF THE INVENTION The present invention relates to inhibition of growth factor tyrosine kinase receptor activity, particularly inhibition of angiogenesis and related disorders, tumor progression and growth factor related skeletal disorders, by porphyrin and corrole compounds, and to certain

EphA2 as a therapeutic target for cancer

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EphA2 as a diagnostic target for metastatic cancer

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FIELD OF THE INVENTION The present invention relates to diagnosis of metastatic disease. More particularly, this invention relates to reagents that can detect a specific epithelial cell tyrosine kinase that is overexpressed in metastatic tumor cells. Most particularly, this invention relates to

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