non-alcoholic fatty liver disease/epileptični krč

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Risk Factors for Prolonged Invasive Mechanical Ventilation in COVID-19 Acute Respiratory Distress Syndrome

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Prijava / prijava

Background On February 21th 2020, SARS-CoV-2 outbreak erupted in Italy and, in the immediately subsequent period, all the Italian regional Health Systems had to face with an overwhelming increase of COVID-19 admissions requiring isolation, oxygen, ventilation and ICU beds. The COVID-19 related

Role of Pharmacotherapy in Counteracting Weight Regain in Adolescents With Severe Obesity

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Prijava / prijava

Severe obesity, afflicting ~8% of adolescents in the U.S., is a serious and challenging medical and public health problem. The number and levels of cardiovascular risk factors are considerably higher in the context of severe obesity compared to milder forms of obesity. Approximately 85% of youth

A Prospective Randomized Controlled Trial on the Use of Cerebral Oximetry in Adult Chinese Patients Undergoing Liver Transplantation

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Prijava / prijava

Liver Transplant Liver transplantation (LT) is a life-saving procedure for patients with end-stage liver disease. Despite continuous advancement in technology, it remains a high-risk operation. The building-up of an oxygen debt during LT can lead to an increased risk of poor postoperative outcomes

Induced Pluripotent Stem Cells for Niemann Pick Disease

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Prijava / prijava

Niemann-Pick disease type C (NPC) is a lipid storage disease that can present in infants, children, or adults. Neonates can present with ascites and severe liver disease from infiltration of the liver and/or respiratory failure from infiltration of the lungs. Other infants, without liver or

Safety and Efficacy of Pre-emptive Tapentadol vs Pregabalin in Post Operative Pain Following Surgery

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Prijava / prijava

MATERIALS AND METHODS After approval of the institutional Ethics committee board, written informed consent will be taken from all the eligible and willing patients. A. Study design: Randomized double blind active controlled parallel group noninferiority clinical trial. B. Randomization: A variable

Lacosamide Effects on Alcohol Self Administration and Craving in Heavy Drinkers

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Prijava / prijava

The present proposal is intended to answer the call for accelerating drug development by exploring the potential of a novel anticonvulsant, lacosamide as a candidate medication for the treatment of AUD. This drug, which is approved for the treatment of seizure disorders, has unique pharmacological

Multimodal Analgesic Technique for Control of Post-laproscopy Abdominal Pain

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Prijava / prijava

The advancement of laparoscopy and minimal access surgery has greatly influenced the evolution of anaesthetic techniques. However, postoperative pain intensity may be significant, with up to 40% of patients unsatisfied by routine analgesia and up to 80%may require rescue opioids during their

The Effect of Cinnamon Cassia on Diabetes Control and Cardiometabolic Risk Factors in Adults With Type 2 Diabetes Mellitus

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Prijava / prijava

Experimental Design: This Phase 2 study will be done prospectively and will be conducted in two stages. The initial stage will be the general study and the second stage will be the sub-study. We plan to screen up to 1,000 subjects. Our enrollment goal is 250 subjects total (with 50 subjects enrolled

Treatment for Alcohol Dependence With Gabapentin

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Prijava / prijava

The study will be conducted on patients with alcohol dependence admitted or coming to the out patient department. The enrolled subjects will be divided into two groups randomly using computer generated randomization system. Informed consent shall be taken from the patient/nearest relative of the

Stroke in Korean Young Adults Study

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Prijava / prijava

All consecutive patients who had their first-ever ischemic stroke symptoms within the previous month will be asked to enroll in the study. Baseline measurements will be assessed in all patients. Patients without language problems or life-threatening conditions will be asked to answer the structured

Ictal SPECT With Intra-arterial Injection

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Prijava / prijava

In this study, the investigators will select one patient with refractory focal epilepsy with frequent seizures of short duration, which can not be localized with early ictal SPECT with intravenous injection in a cubital vein. An arterial catheter will be inserted. The right groin will be disinfected

Nitazoxanide Plus Lactulose Versus Lactulose Alone Treatment of Hepatic Encephalopathy

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Prijava / prijava

Hepatic encephalopathy (HE) is a reversible neuropsychiatric syndrome associated with chronic and acute liver dysfunction. It is characterized by cognitive and motor deficits of varying severity. Hepatic encephalopathy is caused by accumulation of nitrogenous substances, primarily ammonia, in the

Characterization of Neuropsychologic and Physical Performance in Geriatric Patients With Hyponatremia.

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Prijava / prijava

With an occurrence of up to 30%, hyponatremia, defined as a serum sodium concentration of less than 135 mmol/L, is the most commonly encountered electrolyte disorder in hospitalized patients today. The highest incidence of hyponatremia is found in the elderly. Retrospective analyses clearly show an

Efficacy of Switching or Adding Pegylated Interferon in Chronic Hepatitis B Patients on Long Term Oral Antiviral Therapy

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Prijava / prijava

1. HYPOTHESIS AND OBJECTIVES PEG-IFN as an immunomodulatory agent could potentiate the antiviral efficacy of patients on long term nucleos(t)ide analogue therapy and improve early indicators of efficacy, HBeAg loss and reduction in qHBsAg. This study will also test whether add-on compared to switch

Citalopram Effects on Craving and Dopamine Receptor Availability in Alcoholics

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Prijava / prijava

Description of Proposed Study A. Scientific Basis: Alcohol abuse and dependence represent a spectrum of maladaptive behaviors with enormous public health impact, especially for the U.S. Veteran population. Depressive symptoms are frequently comorbid with alcohol use disorders, but despite the

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