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Stran 1 iz 61 rezultatov
New anti-fibrotic mechanisms of n-acetyl-seryl-aspartyl-lysyl-proline in silicon dioxide-induced silicosis.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
OBJECTIVE
We previously reported that tetrapeptide N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) inhibited pulmonary inflammation and fibrosis in SiO(2)-induced silicosis. This study aimed to explore the precise mechanism involved.
METHODS
Rats were divided into 3 groups: 1) sham (saline), 2)
Proline-rich protein is a glycoprotein and an acute phase reactant.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Proline-rich protein (PRP) is a plasma protein associated with lipoproteins. In an attempt to clarify the biological significance of this protein, we isolated and characterized it and studied the biological role in plasma. PRP was isolated by immunosorber column chromatography and by gel filtration
X-linked severe combined immunodeficiency (X-SCID) with high blood levels of immunoglobulins and Aspergillus pneumonia successfully treated with micafangin followed by unrelated cord blood stem cell transplantation.
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Prijava / prijava
In this report, we describe a patient with X-linked severe combined immunodeficiency (X-SCID) who had high serum IgG, IgA, and IgM levels. The boy did well until 6 months of age, when he developed interstitial pneumonia caused by Aspergillus species, with a white cell count of 12,840/microL and only
A Randomized, Placebo-controlled Trial of Roflumilast. Effect on Proline-Glycine-Proline and Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease.
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Prijava / prijava
BACKGROUND
Roflumilast is a therapeutic agent in the treatment of chronic obstructive pulmonary disease (COPD). It has antiinflammatory effects; however, it is not known whether it can affect a biologic pathway implicated in COPD pathogenesis and progression. The self-propagating
Vaccine efficacy of a Mycobacterium tuberculosis Beijing-specific proline-glutamic acid (PE) antigen against highly virulent outbreak isolates.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Bacillus Calmette-Guerin vaccine confers insufficient pulmonary protection against tuberculosis (TB), particularly the Mycobacterium tuberculosis (Mtb) Beijing strain infection. Identification of vaccine antigens (Ags) by considering Mtb genetic diversity is crucial for the development
Bacterial pneumonia causes augmented expression of the secretory leukoprotease inhibitor gene in the murine lung.
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Prijava / prijava
The cDNA of murine secretory leukoprotease inhibitor (SLPI) was cloned from a mouse lung cDNA library. The amino acid sequence deduced from the cDNA showed 58 and 51% homology with those of human and porcine SLPI, respectively. A two-domain structure with similar amino acid sequences, four
The pandemic 2009 (H1N1) swine influenza virus is mild compared to the pandemic 1918 (H1N1) virus because of a proline-to-serine substitution in the receptor-binding site of its hemagglutinin - a hypothesis.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
The relative mildness of the pandemic 2009 (H1N1) swine influenza virus compared to the 1918 pandemic (H1N1) virus may be due to a variety of possible causes, including the existence of effective immunity in the host, the lessened ability of the virus to bind to target cells or to replicate in them,
Imaging of fibrogenesis in patients with idiopathic pulmonary fibrosis with cis-4-[(18)F]-Fluoro-L: -proline PET.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
OBJECTIVE
Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease for which no single diagnostic modality is able to evaluate the activity of the disease process. Cis-4-(18)F-fluoro-L: -proline ((18)F-proline) was shown in animal studies to be a reliable marker for fibrosis formation. We tested
Proline-oxidase and hydroxypyroline-2-epimerase activities in experimental fibrosing granulomatous processes of the lung.
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Prijava / prijava
Three experimental fibrosing granulomatous processes of the lung (pulmonary granulomas induced by complete Freund adjuvant, viral pneumonitis induced by the A2 influenza virus, and tuberculosis induced in animals exposed to tobacco smoke) were produced in rabbits and the results confronted in view
Nucleotide sequences of the genes encoding the putative attachment glycoprotein (G) of mouse and tissue culture-passaged strains of pneumonia virus of mice.
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Prijava / prijava
The sequences of the genes encoding the putative attachment (G) proteins of pathogenic (strain J3666) mouse lung-passaged and nonpathogenic (strain 15) tissue culture-passaged strains of pneumonia virus of mice (PVM) have been determined. In both cases the major polypeptide was synthesised from the
l-Proline protects mice challenged by Klebsiella pneumoniae bacteremia.
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Prijava / prijava
Clinical experience with an L-proline–stabilized 10 %intravenous immunoglobulin (Privigen®): real-life effectiveness and tolerability.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
OBJECTIVE
This retrospective study evaluated the effectiveness and tolerability in clinical practice of an L-proline-stabilized 10 % intravenous immunoglobulin (IVIG; Privigen®) in patients with primary (PID) or secondary immunodeficiency (SID).
METHODS
Patients from 6 centers in Europe and the US
Chemo-attractant N-acetyl proline-glycine-proline induces CD11b/CD18-dependent neutrophil adhesion.
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Prijava / prijava
BACKGROUND
Chronic inflammation in lung diseases contributes to lung tissue destruction leading to the formation of chemotactic collagen fragments such as N-acetylated proline-glycine-proline (N-ac-PGP). In the current study, we investigate whether N-ac-PGP influences β(2)-integrin activation and
Proline-Glycine-Proline Peptides Are Critical in the Development of Smoke-Induced Emphysema.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Chronic obstructive pulmonary disease (COPD) is a major cause of worldwide mortality and is characterized by an excessive airway neutrophilic response. The neutrophil chemoattractant proline-glycine-proline (PGP) and its more potent acetylated form (acPGP) have been found to be elevated in COPD
Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection.
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Prijava / prijava
Bioactive matrix fragments (matrikines) have been identified in a myriad of disorders, but their impact on the evolution of airway inflammation has not been demonstrated. We recently described a pathway where the matrikine and neutrophil chemoattractant proline-glycine-proline (PGP) could be
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