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Stran 1 iz 146 rezultatov
Prevention of multiple system atrophy using human bone marrow-derived mesenchymal stem cells by reducing polyamine and cholesterol-induced neural damages.
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Prijava / prijava
Possible role of polyamines in gyrate atrophy.
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Prijava / prijava
OBJECTIVE
Gyrate atrophy (GA) is marked by hyperornithinemia and lowered ornithine amino transferase (OAT). However there are patients of GA without hyperornithinemia and those with hyperornithinemia without GA. Some cases of GA have been reported to have low lysine. The purpose of the study was to
Polyamine patterns in the cerebrospinal fluid of patients with Parkinson's disease and multiple system atrophy.
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BACKGROUND
Polyamines (PAs) are important modulators of physiological condition, and are associated with neurodegenerative disease. Thus, we investigated the change of PA concentration in the cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) and multiple system atrophy
Interrelationships between polyamines and nucleic acids. IV. Autoradiographic localization of 3 H-putrescine and its metabolites in normal and degenerating peripheral nerves, and spinal ganglia.
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[Relations between polyamines and nucleic acids. II. Biochemical and fine structural studies of peripheral nerves during Wallerian degeneration].
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Accumulation of exogenous polyamines in gerbil brain after ischemia.
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Regionally selective delayed neuronal degeneration is a characteristic sequel of cerebral ischemia. Recent evidence indicates that changes in brain polyamine metabolism may be critical for nerve cell survival after ischemia. Within hours after ischemia, intracellular putrescine levels are greatly
Preliminary longitudinal studies of serum polyamines in patients with colorectal carcinoma.
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Prijava / prijava
Polyamines, whose biosynthesis is a prerequisite for cell proliferation, are potential indicators of malignant growth. In view of this, serum polyamine levels were examined in longitudinal studies of patients with either colorectal carcinoma or Gardner's syndrome (inherited colonic polyposis
Urinary polyamines as markers of cardiac allograft rejection. A clinical evaluation.
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Histologic evaluation of endomyocardial biopsy specimens is the current method of monitoring rejection after cardiac transplantation. Unfortunately, this technique gives a discontinuous evaluation of the recipient immunologic status. A noninvasive marker of immunologic activation and of allograft
Polyamines can protect against ischemia-induced nerve cell death in gerbil forebrain.
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We have previously demonstrated that administration of the polyamines putrescine, spermidine, or spermine can prevent neuronal degeneration in rats during naturally occurring cell death or after injurious treatments such as nerve injury or monosodium glutamate neurotoxicity. The present study
Polyamines in lymphomas: their value in disease staging and monitoring of therapy efficiency.
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Prijava / prijava
The urinary polyamines putrescine and spermindine were evaluated in a population of 49 patients with malignant lymphomas (40 with non-Hodgkin's lymphoma and 9 with Hodgkin's disease). Analyses were performed on a regular basis during the course of treatment. Polyamine levels were found to increase
Effect of hindlimb suspension and clenbuterol treatment on polyamine levels in skeletal muscle.
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Prijava / prijava
Polyamines are unbiquitous, naturally occurring small aliphatic, polycationic, endogenous compounds. They are involved in many cellular processes and may serve as secondary or tertiary messengers to hormonal regulation. The relationship of polyamines and skeletal muscle mass of adductor longus,
Altered polyamine levels in skeletal muscle of patients with myasthenia gravis.
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Forty patients with myasthenia gravis were tested for polyamine content of the musculus sternothyreoideus removed during thymectomy. Cases with slight muscle alteration were found to show elevated values for all the three polyamines (putrescine, spermidine and spermine) examined with an increased
Polyamine concentrations in the brain of vitamin B12-deficient rats.
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To study the pathophysiology of the neuronal degeneration in vitamin B12 deficiency, we investigated the concentrations of the polyamines putrescine, spermidine, and spermine in brain regions and liver using high-performance liquid chromatography with fluorescence detection. Male Wistar rats were
The upstream open reading frame of the mRNA encoding S-adenosylmethionine decarboxylase is a polyamine-responsive translational control element.
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Prijava / prijava
S-Adenosylmethionine decarboxylase (AdoMetDC) is a key enzyme in the pathway of polyamine biosynthesis. The cellular levels of the polyamines specifically regulate AdoMetDC translation through the 5'-leader of the mRNA, which contains a small upstream open reading frame (uORF) 14 nucleotides from
[Activity of uremic toxins and polyamines on organ culture of 7-day-old chick embryo].
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Prijava / prijava
We studied possible effects of uremic toxins and polyamines (PAs) on organ cultures of chick embryo. We added on culture media the lyophilized of total dialysate and its chromatographic peak II obtained with chromatography with Sephadex G 15. The total dialysate and peak II showed toxicity with
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