prostaglandin f/glavobol

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Pro-inflammatory and vasoconstricting prostanoid PGF2α causes no headache in man.

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Prijava / prijava

BACKGROUND During two decades of migraine provocation studies with naturally occurring signalling molecules, vasodilators such as prostaglandin E(2), prostaglandin I(2) (prostacyclin) and prostaglandin D(2) were shown to be able to induce headache in man. To elucidate the role of inflammation and

Identification of a novel prostaglandin f(2alpha) synthase in Trypanosoma brucei.

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Prijava / prijava

Members of the genus Trypanosoma cause African trypanosomiasis in humans and animals in Africa. Infection of mammals by African trypanosomes is characterized by an upregulation of prostaglandin (PG) production in the plasma and cerebrospinal fluid. These metabolites of arachidonic acid (AA) may, in

[Side-effects and risk profile of latanoprost 0.005% (Xalatan)].

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BACKGROUND Latanoprost, a prostaglandin F(2alpha)-analogue, has been widely in use in clinical practice for a period of over 5 years. The side-effects of latanoprost are analyzed and the clinical relevance is discussed. RESULTS Hypertrichosis and increased pigmentation of eyelashes will develop in

Migraine--a haematological disorder?

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We analysed 22 patients suffering from migraine to evaluate the possible activation of platelet function utilizing the following methods: platelet factor 4, thromboxane B2 and 6 - keto prostaglandin F 1 alpha levels in platelet poor plasma. Laboratory tests were performed on all patients during

Neurogenic vasodilation in rabbit basilar isolated artery: involvement of calcitonin-gene related peptide.

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Prijava / prijava

Neurogenic vasodilation in cranial arteries may be an important mechanism in the pathogenesis of migraine headache. We describe a novel, in vitro assay to characterise neurogenic vasodilator responses in endothelium-denuded segments of rabbit isolated basilar artery, with particular focus on

Prostaglandins in migraine: update.

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OBJECTIVE This review presents recent findings on the role of prostaglandins in migraine pathophysiology. RESULTS Experimental studies have shown that prostaglandins are distributed in the trigeminal-vascular system and its receptors are localized in the trigeminal ganglion and the trigeminal

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