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Stran 1 iz 91 rezultatov
[Protective effect of reserpine on the lesions in acute myocardial degeneration induced by DL-amphetamine and the suppression of this action by monoamine oxidase inhibitors].
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The degeneration contraction of a sympathetically innervated smooth muscle in the rat after reserpine, inhibition of monoamine oxidase or tyrosine hydroxylase.
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Localization of fenfluramine and reserpine in brain regions of rats with extensive degeneration of 5-hydroxytryptaminergic neurons.
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Effect of reserpine on growth and sexual development of chickens.
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One-month-old male chickens were given injections of 1 mg, 2 mg and 4 mg/kg of reserpine. The injections were repeated at weekly intervals for three months. The chickens receiving reserpine grew at half the rate of untreated control chickens and failed to grow combs. At 4 months of age the testes of
The effect of reserpine treatment on the extraneuronal uptake of [3H]-isoprenaline into rat atria.
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Treatment of rats with reserpine (1 mg kg-1 day-1) for up to 7 days resulted in a marked decrease in a corticosterone-sensitive component of the extraneuronal accumulation of [3H]-isoprenaline into their atria. The change in extraneuronal uptake did not appear to be due to a direct action of
[Effect of reserpine on the ultrastructure and electrical instability of the heart].
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The time course of ultrastructural and electrophysiological disorders and their role in sudden death of ventricular fibrillation at various intervals of desympathization caused by reserpine administration were studied. Early in the effect of reserpine (up to 30 min), glycogen granules were found to
Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats 8). Effects of daily subcutaneous administration of reserpine on spermatogenesis for 2 and 4 weeks.
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To obtain information on the validity and the limitations of 2-weeks repeated-dose toxicity studies to detect effects on the male genital organs of rats, reserpine was administered daily at 0.05 and 0.1 mg/kg by subcutaneous injection to Crj:CD(SD)IGS male rats for 2 and 4 weeks (2-weeks and 4-weeks
Quinolinic acid: effects on brain catecholamine and c-AMP content during L-dopa and reserpine administration.
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The catecholamine content in rat brain tissue was determined following the administration of quinolinic acid alone or combined either with L-dopa and decarboxylase inhibitor or reserpine. Quinolinic acid alone decreased the levels of dopamine and noradrenaline, as well as those of c-AMP, and
Reserpine treatment of Raynaud's disease.
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Six patients with primary Raynaud's disease were investigated with magnification hand arteriography, measurement of finger systolic pressure and response to a newly devised local cooling test. They were treated with reserpine 0.5 mg injected into the brachial artery, and the clinical effects were
Effect of reserpine on cell proliferation in the developing rat brain: a quantivative histological study.
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Rats aged 11 days were injected with reserpine (2.5 mg/kg body wt.) and the rate of [3H]thymidine incorporation into brain DNA was followed over a period of 36h. In the forebrain this was significantly depressed by 2h, and it reached a nadir of about 30% of the control level at 4h, at which it
Influence of chronic exercise on reserpine-induced oxidative stress in rats: behavioral and antioxidant evaluations.
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Several neurological diseases are related to oxidative stress (OS) and neurotoxicity. Considering that physical exercise may exert beneficial effects on antioxidant defenses, our objective was to evaluate the influence of a swimming exercise on an OS animal model (reserpine-induced orofacial
Reserpine does not prevent 3,4-methylenedioxymethamphetamine-induced neurotoxicity in the rat.
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3,4-Methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a known neurotoxin to 5-hydroxytryptamine (5-HT) nerve terminals. Recent studies have suggested that endogenous dopamine (DA) and/or 5-HT may mediate the MDMA-induced neurotoxicity. The central monoamine stores of rats were significantly
Differential effects of 5,7-dihydroxytryptamine-induced serotoninergic degeneration of 5-HT1A receptors and 5-HT uptake sites in the rat brain.
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The time-course of 5,7-dihydroxytryptamine-induced lesions (2, 5 and 14 days after i.c.v. injection of 150 micrograms) and the effects of acute reserpine treatment (10 mg/kg, i.p., one or 5 days before scheduled death), were evaluated by autoradiography of [3H]paroxetine binding sites in the rat
Reserpine-induced supersensitivity in rat caudal artery: influence of age.
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Vascular smooth muscle function does not necessarily deteriorate with advancing age. However, although base-line function may be well maintained, the ability to adapt to stress may decline. Therefore we tested the hypothesis that development of denervation supersensitivity may be impaired in older
Differential effects of reserpine and 6-hydroxydopamine on neuropeptide Y (NPY) and noradrenaline in peripheral neurons.
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The effects of 6-hydroxydopamine (6-OHDA) and reserpine pretreatment on peripheral neuropeptide Y (NPY)- and noradrenaline (NA)-containing neurons were studied in guinea-pigs. Ten days after 6-OHDA pretreatment, a 60-80% reduction of the NA content was observed in the right atrium of the heart,
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