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Stran 1 iz 19 rezultatov
Reserpine in weight reduction. The effect in obese patients on 1,000-calorie diets: a controlled study.
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In a controlled study (the control group receiving pyribenzamine) it was observed that reserpine, in the dosage used, had no effect on weight loss in patients receiving d-amphetamine sulphate (Dexedrine(R)) and methyl cellulose (Cellothyl(R)) while on 1,000-calorie diets as compared with the control
Obesity--an approach to the problem with methamphetamine-reserpine combined therapy.
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Hypothalamic catecholamine systems in genetically obese mice (obob): decreased sensitivity to reserpine treatment.
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Systemic administration of 5-HT(2C) receptor agonists attenuates muscular hyperalgesia in reserpine-induced myalgia model.
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Fibromyalgia is a prevalent musculoskeletal disorder characterized by chronic widespread pain that significantly reduces quality of life in patients. Due to the lack of consistently effective treatment, the development of improved therapies for treating fibromyalgia is necessary. As dysfunction of
Cholecystokinin receptors in brain: effects of obesity, drug treatment, and lesions.
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High affinity binding sites specific for cholecystokinin (CCK) and related peptides have been identified in brain. These receptors are regionally distributed, with the greatest density in the caudate nucleus and olfactory bulbs. The number of forebrain CCK receptors increases postnatally to a peak
[Behavior of plasma cortisol during testing with insulin and with LVP in obese subjects compared to normal subjects after resperine administration].
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The behaviour of plasma cortisol levels was studied in fifteen overweight subjects with comparison to normal subjects. In eight subjects the insulin hypoglycemic test was performed before and after medication with reserpine (4mg/24HR); the other seven subjects were tested with LVP before and after
Expression of nerve growth factor in brown adipose tissue: implications for thermogenesis and obesity.
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The presence of nerve growth factor (NGF) and the ability of adrenergic stimulation to affect the rate of its synthesis in mouse, rat, and human brown adipose tissue (BAT) were investigated. Addition of conditioned medium, obtained from preconfluent and confluent brown adipocytes, to PC12 cells
Differential autonomic nervous system response in obese and anorexic chickens (Gallus gallus).
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Effect of reserpine on body weight (BW), feed intake (FI), brain and plasma catecholamine and indoleamine concentrations in high- (HWS) and low- (LWS) weight selected lines of chickens was investigated. Chicks from each line were assigned to three treatment groups and injected intraperitoneally with
Present and future pharmacological approaches.
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There is evidence that drugs altering food intake such as dexfenfluramine, sibutramine and orlistat have useful therapeutic effects, with an acceptable side effect profile. 'Thermogenic' drugs, such as ephedrine and caffeine, are also effective, but less well tolerated and may, in any case, work by
Biochemical and pharmacological evaluation of the novel antidepressant and serotonin uptake inhibitor 2-(3,4-Dichlorobenzyl)-2-dimethylamino-1-propanol hydrochloride.
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2-(3,4-Dichlorobenzyl)-2-dimethylamino-1-propanol, hydrochloride (JO 1017) is a novel antidepressant drug. Its biochemical and pharmacological properties were investigated in mice, rats, dogs, rabbits and guinea pigs. In vitro, it selectively inhibited serotonin uptake and had a high affinity for
Cannabinoid CB1 receptor inverse agonist MJ08 stimulates glucose production via hepatic sympathetic innervation in rats.
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As a key insulin target tissue for maintaining systemic glucose homeostasis, the liver plays important roles in improving obesity-associated insulin intolerance via selective cannabinoid CB1 receptor antagonism/inverse agonism. However, it is unclear whether this receptor inverse agonism affects
Effect of withdrawal of antihypertensive drug on depressive mood.
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To evaluate the effects on depressive mood of withdrawal of antihypertensive medication, we conducted a randomized, multi-center study with clinical centers at the Albert Einstein College of Medicine, Bronx, NY, University of Alabama School of Medicine, Birmingham, and the University of Mississippi
An approach to the treatment of hypertension in the aged.
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Because of the multiplicity of disease conditions and diminished tolerance for drugs in the aged, it is necessary to know concomitant pathologic conditions to determine which antihypertensive drug to use. In the Philadelphia Geriatric Center, there are about 1,000 residents, between 70 and 100 years
Major new developments affecting treatment and prognosis in hypertension.
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Joint studies of the ALIMDA and Society of Actuaries, notably those of 1935, 1959 and 1979, established that there is a progressive rise in cardiovascular mortality with successive increments in blood pressure. This has provided the basis of underwriting. The converse is not true, or at least has
Progress in assessing the role of serotonin in the control of food intake.
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There is evidence that serotonin inhibits food intake, particularly intake of carbohydrate and that induced by activation of catecholamine-containing neurons in different brain circuits. An agent that has contributed considerably to the hypothesis of a role of serotonin in feeding is fenfluramine,
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