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12 rezultatov
On the mechanism of diarrhea due to reserpine.
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Prijava / prijava
Reserpine toxicosis in a horse.
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Prijava / prijava
A single injection of reserpine in an adult horse was believed to induce toxicosis for several days. Clinical signs included erratic, colic-like behavior followed by depression, bradycardia, miosis, ptosis, and paraphimosis. Diarrhea was not observed and may have been due to the effect of xylazine
A comparison of peripheral and central effects of clonidine on rat intestinal transit.
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Prijava / prijava
This study was designed to examine the effects of centrally or peripherally administered clonidine on small intestinal transit (SIT) in rats with diarrhea. Adult, male rats weighing 200 to 250 grams were surgically implanted with a silicone catheter in the proximal small intestine. Some animals were
[Pharmacological properties of MO-8282, a novel antidepressant].
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Prijava / prijava
The pharmacological properties of MO-8282 (1,2,3,4-tetrahydro-2-methyl-9H-dibenzo [3,4: 6,7]cyclohepta [1,2-c]pyridine maleate) as an antidepressant were investigated. At doses 10 times less than those of amitriptyline, MO-8282 showed similar potencies in reducing the duration of immobility during
Light and electron microscopic studies of pathologic changes induced in mice by ciguatoxin poisoning.
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Prijava / prijava
Acute poisoning induced by ciguatoxin or ciguatoxin-4c in male ICR mice was examined by light and electron microscopy. Target organs were the heart, medulla of adrenal glands, autonomic nerves and penis. There were no significant differences between the toxicity of ciguatoxin and ciguatoxin-4c.
Characteristics of inflammation induced by fusarenon-X, a trichothecene mycotoxin from Fusarium species.
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Prijava / prijava
Fusarenon-X (F-X) is one of the trichothecene mycotoxins, which have been suggested to induce Fusarium mycotoxicoses. Administration of F-X to experimental animals causes diarrhea, skin irritation, and foot edema. In the present work the properties of F-X-induced inflammation were examined. F-X
Ontology-based systematical representation and drug class effect analysis of package insert-reported adverse events associated with cardiovascular drugs used in China.
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Prijava / prijava
With increased usage of cardiovascular drugs (CVDs) for treating cardiovascular diseases, it is important to analyze CVD-associated adverse events (AEs). In this study, we systematically collected package insert-reported AEs associated with CVDs used in China, and developed and analyzed an Ontology
Antidepressant-like effect of ethanol extract of Blighia unijugata Bak. (Sapindaceae) leaves in acute and chronic models of depression in mice.
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Prijava / prijava
Blighia unijugata (Sapindaceae) is an indigenous tree belonging to the tropical forests of West Africa. It is called "Ako Isin" by the Yoruba people of Southern-Western part of Nigeria, where it is among plants used traditionally in the management of depressive psychosis. The aim of this
Pharmacological investigations on lonidamine.
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Prijava / prijava
The results of a broad pharmacological screening on 1-[(2,4-dichlorophenyl)-methyl] -1H-indazole-3-carboxylic acid ( lonidamine ) a new antitumour agent which also possesses antispermatogenic and embryotoxic effects, are reported. Lonidamine does not affect general behaviour and autonomic functions
Evaluation of Antidepressant-like Effect of Olax Subscorpioidea Oliv. (Olacaceae) Extract in Mice.
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Prijava / prijava
Olax subscorpioidea is a shrub or tree found in Nigeria, and other parts of Africa. It is indicated in the management of inflammatory disorder, mental illness, convulsion, pain, and cancer.Based on the folkloric use in the management of mental illness, antidepressant activity of Olax subscorpioidea
An Indian Desert Shrub 'Hiran Chabba', Farsetia Hamiltonii Royle, Exhibits Potent Antioxidant and Hepatoprotective Effect Against Iron-Overload Induced Liver Toxicity in Swiss Albino Mice.
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Prijava / prijava
BACKGROUND
Farsetia hamiltonii Royle, also known as Hiran Chabba grows in desert regions. It is widely used as folk medicine to treat joint pains, diarrhea and diabetes. However, its antioxidant and iron chelation abilities both in vitro and in vivo have not yet been investigated.
METHODS
The 70%
By what mechanism does ondansetron inhibit colonic migrating motor complexes: does it require endogenous serotonin in the gut wall?
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Prijava / prijava
BACKGROUND
5-HT3 antagonists, such as ondansetron (Zofran), retard colonic transit and provide effective relief of symptoms of chronic diarrhea and diarrhea-predominant irritable bowel syndrome (IBS), but the mechanism by which ondansetron retards transit is unclear. What is clear is that the
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