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Studies of the pathogenesis of anemia of inflammation: mechanism of impaired erythropoiesis.

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Prijava / prijava

Cats with induced sterile abscesses developed a hematologic disorder consistent with anemia of inflammation. Serum iron concentrations decreased while the abscess was present, but erythropoietin concentrations did not change significantly. Cobalt administration to control (healthy) cats resulted in

Reticulocytosis in nonanemic dogs: increasing prevalence and potential etiologies.

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Prijava / prijava

BACKGROUND An increasing prevalence of reticulocytosis in the absence of anemia (RAA) in dogs has been suspected in recent years. OBJECTIVE The objectives were to determine whether prevalence of RAA in our canine population has been increasing over the last years, and to identify potential

Reticulocytosis in non-anaemic cats and dogs.

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Prijava / prijava

OBJECTIVE To evaluate the proportion of blood samples diagnosed with reticulocytosis without anaemia in cats and dogs and report the aetiology and mortality rate of affected animals. METHODS Retrospective multicentre study including haematological examination of 3956 cats and 11,087 dogs admitted to

HMGB1 mediates anemia of inflammation in murine sepsis survivors.

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Prijava / prijava

Patients surviving sepsis develop anemia, but the molecular mechanism is unknown. Here we observed that mice surviving polymicrobial gram-negative sepsis develop hypochromic, microcytic anemia with reticulocytosis. The bone marrow of sepsis survivors accumulates polychromatophilic and orthochromatic

Subacute toxicity of primaquine in dogs, monkeys, and rats.

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Prijava / prijava

Certain derivatives of the 8-aminoquinolines have been shown to affect some blood constituents and haemopoiesis, to induce functional changes in the central nervous system, and to cause other organ lesions. The 8-aminoquinolines vary widely in their toxicity and ability to induce tissue damage in

Intravenous immunoglobulin-related hemolysis in patients treated for Kawasaki disease.

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Prijava / prijava

BACKGROUND Kawasaki disease (KD) is an idiopathic, multisystem disorder characterized by vasculitis of arteries, veins, and capillaries, affecting pediatric patients, and is the leading cause of acquired heart disease in childhood. The mainstays of therapy for KD are high-dose intravenous

STAT6-mediated suppression of erythropoiesis in an experimental model of malarial anemia.

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Prijava / prijava

BACKGROUND The contribution of pro-inflammatory cytokines to the pathogenesis of malarial anemia has been studied extensively but the roles of Th2 cytokines remain unknown. Here, we investigated the role of signal transducer and activator of transcription (STAT)6-mediated responses in erythropoietic

Preferential Elimination of Older Erythrocytes in Circulation and Depressed Bone Marrow Erythropoietic Activity Contribute to Cadmium Induced Anemia in Mice.

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Prijava / prijava

Feeding cadmium chloride (50 or 1000 ppm CdCl2 in drinking water, ad libitum) to C57BL/6 mice resulted in a significant and sustained fall in blood erythrocyte count and hemoglobin levels that started 4 and 3 weeks after the start of 50 and 1000 ppm cadmium doses respectively. A transient yet

Hemozoin (malarial pigment) directly promotes apoptosis of erythroid precursors.

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Prijava / prijava

Severe malarial anemia is the most common syndrome of severe malaria in endemic areas. The pathophysiology of chronic malaria is characterised by a striking degree of abnormal development of erythroid precursors (dyserythropoiesis) and an inadequate erythropoietic response in spite of elevated

[Hematologic anomalies in Lyell's syndrome. Study of 26 cases].

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Prijava / prijava

Case records of 26 patients with Lyell Syndrome were reviewed for studying haematologic abnormalities. Eosinophilia, neutropenia, thrombopenia were uncommon. Circulating immature granulocytic cells were frequently encountered during the second week of evolution, mostly when leucocytosis was present.

Case report: hemolytic anemia produced by tolmetin.

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Prijava / prijava

Tolmetin, a nonsteroidal anti-inflammatory drug, was found to be the etiologic agent in a case of drug-induced hemolytic anemia. A 35-year-old female who had ingested tolmetin sporadically in the past took two doses that resulted in acute hemolysis. Two days after taking the second dose, she had a

Enhanced mobilization of iron from body stores in malnourished patients during intravenous nutritional support.

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Prijava / prijava

Abnormal iron metabolism, characterized by low serum iron concentration and diminished saturation of iron-binding capacity, is known to occur in patients with malignant or inflammatory diseases. In this study, serum iron concentration and iron-binding capacity were measured in 21 patients with

Does sulphasalazine cause folate deficiency in rheumatoid arthritis?

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Prijava / prijava

Sulphasalazine impairs folic acid absorption and metabolism but rarely leads to folate deficiency in inflammatory bowel disease (IBD). In rheumatoid arthritis (RA), however, serum and red cell folate concentrations are often low and sulphasalazine might stress folate metabolism. In a prospective

Single-dose and repeated-exposure toxicity of a complex wastewater from munitions manufacturing plants.

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Prijava / prijava

The single-dose and repeated-exposure toxicity of a synthetic mixture of 30 nitrotoluene analogs, representative of a complex industrial wastewater termed condensate water, was evaluated in dogs, rats, and mice. The single-dose oral LD50s for the synthetic condensate water (CW) were 447 and 295

Severe Hyperkalemia Immediately After Birth.

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Prijava / prijava

BACKGROUND Hyperkalemia is an important cause of arrhythmias and a medical emergency that requires urgent treatment. The etiology is usually multifactorial. It is most frequently caused by impaired potassium secretion, followed by transcellular potassium shifts and an increased potassium load. CASE

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