taxus baccata/preobčutljivost

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Taxus baccata allergy in a breast cancer patient.

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[Desensitisation to circumvent hypersensitivity reactions; treatment with docetaxel still possible].

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A 57-year-old woman with advanced non-small cell lung carcinoma developed hypersensitivity reactions to docetaxel. Measures taken to attempt the re-administration of docetaxel failed. For the differential diagnosis, an IgE specific to docetaxel (in terms of cross-reactivity with Taxus baccata), the

Taxanes in Taxus baccata pollen: cardiotoxicity and/or allergenicity?

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Prijava / prijava

Diterpenic alkaloids belonging to taxine (yield: 0.18 % dry weight) and taxoids (paclitaxel, baccatine III and 10-deacetylbaccatine III, cumulated yield: 0.004 % dry weight) were isolated from Taxus baccata L. pollen. Moreover, taxoids conjugated to macromolecules were also detected by ELISA.

[Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center].

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OBJECTIVE To analyze the types, frequency and severity of plant poisonings in Switzerland over 29 years. METHODS Retrospective analysis of severe poisonings with toxic plants reported to the Swiss Toxicological Information Center (STIC). Assessment of the causality, severity of symptoms and the

An epidemiological survey of Cupressaceae pollenosis in Italy.

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Allergic reaction to Cupressaceae and Taxodiaceae pollens appears to be on the increase in the last years in Italy. An epidemiological survey on this pollenosis was conducted in 12 Italian centers. The diagnostic panel consisted of seven Cupressaceae and Taxodiaceae genus (Cupressus sempervirens,

A phase II trial with docetaxel (Taxotere) in second line treatment with chemotherapy for advanced breast cancer. A study of the EORTC Early Clinical Trials Group.

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BACKGROUND Docetaxel, a semisynthetic analog of paclitaxel, made for the needles of the European yew, Taxus baccata, is a potentially important chemotherapeutic agent for the treatment of cancer. METHODS In a phase II study patients with advanced and/or metastatic breast cancer and bidimensionally

A late phase II study of RP56976 (docetaxel) in patients with advanced or recurrent breast cancer.

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Prijava / prijava

A late phase II clinical trial of RP56976 (docetaxel), derived from Taxus baccata was performed to evaluate anti-tumour activity, time to progression and clinical toxicity in patients with advanced or recurrent breast cancer. The patients, between 15 and 80 years old with performance status (PS) of

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury

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The taxanes or taxoids are a closely related group of antineoplastic agents that have a unique mechanism of action as inhibitors of mitosis and which are widely used in the therapy of ovarian, breast, lung, esophageal, prostate, bladder and head and neck cancers. Three taxanes are in clinical use,

Current status of Taxotere (docetaxel) as a new treatment in breast cancer.

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Therapy for advanced breast cancer has not improved significantly in recent years, remaining strictly palliative in nature and intent. One approach to increase the effectiveness of the treatment is the introduction of active new drugs. Taxotere (docetaxel) is a taxoid derivative isolated from the

Phase II trial of docetaxel (Taxotere) in metastatic colorectal carcinoma.

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BACKGROUND Docetaxel (Taxotere) is prepared from a noncytotoxic precursor extracted from the needles of the Taxus baccata. Preclinical investigations have demonstrated that docetaxel is very active in colon adenocarcinoma murine models. Phase I studies revealed granulocytopenia to be the

Paclitaxel (Taxol) and docetaxel (Taxotere): active chemotherapeutic agents in lung cancer.

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Prijava / prijava

Paclitaxel (Taxol), the prototype of a new class of plant-derived antineoplastic compounds, is a natural product isolated from the Pacific yew. Docetaxel (Taxotere) is a hemisynthetic product derived from the European yew. These agents share a unique mechanism of cytotoxic action by promoting

Update on taxane development: new analogs and new formulations.

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The taxanes (paclitaxel and docetaxel) represent an important class of antineoplastic agents that interfere with microtubule function leading to altered mitosis and cellular death. Paclitaxel (Taxol(®)) was originally extracted from a yew tree (Taxus spp., Taxaceae) a small slow-growing evergreen,

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