theophylline/dental caries

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Effects of caffeine and theophylline on the development of dental caries in rats.

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Prijava / prijava

The purpose of this study was to evaluate the influence of caffeine and theophylline on the development of dental caries in rats. Six Wistar dams (spf), mutans streptococci free, were obtained, each with six male pups. The dams were infected by Streptococcus sobrinus 6715 and divided into three

A Cyclodextrin-Stabilized Spermine-Tagged Drug Triplex that Targets Theophylline to the Lungs Selectively in Respiratory Emergency

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Prijava / prijava

Ion-pairing a lifesaving drug such as theophylline with a targeting moiety could have a significant impact on medical emergencies such as status asthmaticus or COVID-19 induced pneumomediastinum. However, to achieve rapid drug targeting in vivo the ion-pair must be protected against breakdown before

[Change in the drug release behavior of theophylline sustained-release tablets after division into two halves].

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Prijava / prijava

Dividing a tablet into two halves and providing them to patients is a routine approach in clinical practice. Obviously, the drug release behavior of tablets should be constant, regardless of the dividing process. Here, we investigated the change in drug release behavior after dividing tablets into

Structure-related pharmacokinetics of xanthines after direct administration into the peritoneal cavity of rats.

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Prijava / prijava

The pharmacokinetic characteristics, peritoneal permeability and hydrophobicity of three xanthine derivatives, theophylline, enprofylline and 1-methyl-3-propylxanthine (MPX), were investigated in rats. Isotonic saline (30 ml) containing xanthine (2.5, 5 and 10 mg/kg) and blue dextran (0.2%) was

Surface-enhanced Raman scattering sensor for theophylline determination by molecular imprinting on silver nanoparticles.

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Prijava / prijava

A surface-enhanced Raman scattering (SERS)-based sensor for the determination of theophylline (THO) has been developed by imprinting the target molecules on the surface of silver nanoparticles. The desired recognition sites are generated after template removal and homogeneous distribution on the

Anti-inflammatory effects of theophylline, cromolyn and salbutamol in a murine model of pleurisy.

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Prijava / prijava

1. The aim of this study was to examine the effect of theophylline, cromolyn and salbutamol, three well-known anti-asthmatic drugs, on the early (4 h) and late (48 h) phases of cell migration and fluid leakage induced by carrageenin in the pleural cavity of mice. 2. In the first set of experiments,

Development and characterization of buoyant theophylline microspheres with near zero order release kinetics.

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Prijava / prijava

The objective of this study was to prepare floating theophylline microspheres with zero order release profiles for use as buoyant reservoirs with increased retention time in the stomach. The microspheres were prepared by a modified emulsion-solvent evaporation method using a polymer mixture of

Effect of theophylline and adenosine on eosinophil function.

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Prijava / prijava

Eosinophils may play a critical role in asthma and bronchial hyperresponsiveness, yet the effect of theophylline on their function is not certain. We have examined the effects of theophylline on opsonized zymosan-induced superoxide anion (O2-) release from guinea pig eosinophils harvested from the

Pharmacokinetics of theophylline and phenobarbital during peritoneal dialysis compared with intestinal dialysis in rats.

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Prijava / prijava

The transfer rates of theophylline and phenobarbital from blood into the peritoneal cavity were investigated after their intravenous administrations at a dose of 10 mg/kg each in rats. Appreciable amounts of both drugs were transported into the dialysate with their transfer rates decreasing as the

Comparison of intestinal and peritoneal dialysis of theophylline and phenobarbitone in rats.

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Prijava / prijava

Intestinal dialysis of drugs by oral administration of activated charcoal has been compared with peritoneal dialysis in rats. The average amounts of theophylline transported over 120 min into the intestinal lumen and the peritoneal cavity were 15.7 and 16.5% of the intravenous dose (10 mg kg-1),

Analysis of the inflammatory response induced by substance P in the mouse pleural cavity.

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Prijava / prijava

This study analyzes both cell migration and exudation responses elicited by substance P (SP) in the mouse pleural cavity. SP caused, 4 h after its administration into the mouse pleural cavity, a dose-related recruitment of leukocytes (ED50 = 14.2 nmol), mainly due to mononuclears. Leukocytes peaked

Recognition mechanism of theophylline-imprinted polymers: two-dimensional infrared analysis and density functional theory study.

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Prijava / prijava

Molecular imprinting polymers (MIPs) are synthetic materials having specific cavities tailored for a target molecule. Thoroughly understanding the molecular recognition mechanism is favorable for the rational design, preparation, and application of MIPs. In this work, theophylline (THO)-imprinted

Spectroscopic and computational insights into theophylline/β-cyclodextrin complexation: inclusion accomplished by diverse methods.

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Prijava / prijava

Current scenario in asthmatic prevalence worldwide calls for a facile, cost-effective, and energy efficient methodology to formulate the potent bronchodilator, theophylline (THP), into an effective dosage forms. Since the uses of THP are severely impeded by its poor aqueous solubility and low

[Assessment of oral cavity mucosa and teeth state in patients with chronic obstructive pulmonary disease--part I].

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Prijava / prijava

The aim of the study was to assess the state of oral cavity mucosa and teeth in patients with chronic obturative pulmonary disease (COPD). METHODS The study comprised 100 patients with COPD (68 men and 32 women), aged 30-83 years (mean 63.1 +/- 10.17 years). All patients demonstrated II grade COPD

Novel Dissolution Method for Oral Film Preparations with Modified Release Properties.

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Prijava / prijava

Oromucosal film preparations have gained popularity in pharmaceutical research and development. Therefore, oral films have been integrated into the monograph "oromucosal preparations" of the European Pharmacopeia in 2012. Regulatory authorities explicitly demand dissolution studies for

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