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Interictal discharges in tungsten foci and EEG seizure activity.

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Simultaneous glutamate and EEG activity measurements during seizures in rat hippocampal region with the use of an electrochemical biosensor.

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Excessive release of L-glutamic acid (glu) has been associated with seizures and epilepsy. Some microdialysis studies have demonstrated an increase in glu levels during seizures both in human and in different animal models of experimental epilepsy. With these techniques it is difficult to monitor

MRI compatible optrodes for simultaneous LFP and optogenetic fMRI investigation of seizure-like afterdischarges.

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In preclinical studies, implanted electrodes can cause severe degradation of MRI images and hence are seldom used for chronic studies employing functional magnetic resonance imaging. In this study, we developed carbon fiber optrodes (optical fiber and electrode hybrid devices), which can be utilised

Tungsten determination in biological fluids, hair and nails by plasma emission spectrometry in a case of severe acute intoxication in man.

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A healthy 19-year-old recruit in a French artillery regiment drank 250 mL of a mixture of beer and wine that had rinsed in a hot 155-mm gun-barrel. Fifteen minutes later, he complained of nausea followed by seizures. He was comatose for 24 h, presenting signs of encephalopathy. A moderate renal

Spike-wave complexes and fast components of cortically generated seizures. I. Role of neocortex and thalamus.

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We explored the relative contributions of cortical and thalamic neuronal networks in the generation of electrical seizures that include spike-wave (SW) and polyspike-wave (PSW) complexes. Seizures were induced by systemic or local cortical injections of bicuculline, a gamma-aminobutyric acid-A

Analysis of chronic seizure onsets after intrahippocampal kainic acid injection in freely moving rats.

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OBJECTIVE The goal of this study was to analyze the transition period between interictal and ictal activity in freely moving rats with recurrent spontaneous seizures after unilateral intrahippocampal kainic acid (KA) injection. METHODS Pairs of tungsten electrodes (50 microm O/D) were implanted

GABAA-mediated IPSCs in piriform cortex have fast and slow components with different properties and locations on pyramidal cells.

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GABAA-mediated IPSCs in piriform cortex have fast and slow components with different properties and locations on pyramidal cells. J. Neurophysiol. 78: 2531-2545, 1997. A recent study in piriform (olfactory) cortex provided evidence that, as in hippocampus and neocortex, gamma-aminobutyric acid-A

[The effects of intravenous lidocaine on the activity of medullary respiratory neurons in cats].

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The effects of intravenous lidocaine on the activity of medullary respiratory neuron were studied in urethane anesthetized cats. Using a tungsten microelectrode, spikes from medullary inspiratory neurons were recorded around nucleus ambiguous. Lidocaine was administered using a constant-rate

Molecular basis of the biological function of molybdenum: the relationship between sulfite oxidase and the acute toxicity of bisulfite and SO2.

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The administration of tungsten to rats maintained on a low molybdenum diet resulted in a dose- and time-dependent loss of sulfite oxidase (EC 1.8.3.1) and xanthine oxidase (EC 1.2.3.2) activities and hepatic molybdenum. These tungsten-treated animals appeared healthy, but were more susceptible to

Higher susceptibility of cerebral cortex and striatum to sulfite neurotoxicity in sulfite oxidase-deficient rats.

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Patients affected by sulfite oxidase (SO) deficiency present severe seizures early in infancy and progressive neurological damage, as well as tissue accumulation of sulfite, thiosulfate and S-sulfocysteine. Since the pathomechanisms involved in the neuropathology of SO deficiency are still poorly

In vivo modulation of hippocampal epileptiform activity with radial electric fields.

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OBJECTIVE Electric field stimulation can interact with brain activity in a subthreshold manner. Electric fields have been previously adaptively applied to control seizures in vitro. We report the first results from establishing suitable electrode geometries and trajectories, as well as stimulation

Amygdala kindling and associated changes of entorhinal responses in suckling rats.

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Entorhinal field potential with amygdala stimulation in suckling (16-18 days old) and adult rats was recorded with a tungsten wire electrode (tip diameter 2-5 microns) to study the developmental changes in behavioral seizures and long-term potentiation (LTP) in the responses to amygdala kindling

Corpus callosum and propagation of afterdischarge to contralateral cortex and thalamus.

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The patterns of seizure spread were investigated in cats with experimental seizure foci in the motor cortex. Recordings were made with tungsten microelectrodes. When convulsive activity developed at the focus, there was activation of the ipsilateral thalamus before there was propagation of

Pathologic electrographic changes after experimental traumatic brain injury.

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To investigate possible electroencephalography (EEG) correlates of epileptogenesis after traumatic brain injury (TBI) using the fluid percussion model. Experiments were conducted on adult 2- to 4-month-old male Sprague-Dawley rats. Two groups of animals were studied: (1) the TBI group with depth and

Neurons in human epileptic cortex: correlation between unit and EEG activity.

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A total of 90 neurons were recorded extracellularly from 17 awake patients undergoing craniotomy for excision of epileptogenic cortex. Relationships between single-unit activity and gross epileptiform spikes recorded locally by the microelectrode or from the immediate overlying cortical surface by

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