Analgesic and anti-inflammatory activity of stereoisomers of carane derivatives in rodent test.
Fjalë kyçe
Abstrakt
Our previously conducted pharmacological investigations led us to discovery of the strong local anesthetic activity of the compound KP-23RS. The following studies revealed that its R- and S-diasteroisomers had different activity in the local anesthetic, anti-aggregating, anti-arrhythmic and spasmolytic tests. Also the influence of KP-23RS and its diastereoisomers on the cyclic adenosine monophosphate (AMP) generating system was described. In the present study, anti-inflammatory and analgesic effects of these compounds were investigated in hind paw edema test, Randall's analgesia test and hot-plate test. Also the spasmolytic activity and the influence on the stomach mucous membrane were examined. All of these compounds had an anti-inflammatory and analgesic activity in hot-plate test and in Randall's test. Moreover, compound KP-23R showed spasmolytic activity. None of the investigated compounds induced damage of the mucous membrane of the rat stomach.