[Effect of pyruvate on metabolic processes in erythrocytes after acute massive blood loss].
Fjalë kyçe
Abstrakt
It is shown in the in vitro experiments that addition into the incubation medium of 10 mumol pyruvate is accompanied by the inhibition of the lactate dehydrogenase activity. The level of 2.3-biphosphoglycerate, ATP, lactate and hemoglobin increases by 92%, 265%, 93% and 56%, respectively. The acute massive haemorrhage against a background of infusion of 0.065% solution of pyruvate does not evoke a decrease in the hemoglobin level, which is observed after infusion of the physiological solution. The value of hematocrit proved to be higher to some extent. The 2,3-biphosphoglycerate level and the activity of glucoso-6-phosphate dehydrogenase are not changed in comparison with the results of intact rats. The glutathione reductase activity rises by 38%. The lactate level diminishes by 34%. Pyruvate is established to exert a therapeutic effect in acute massive haemorrhage. The survival rate of rats after infusion of pyruvate increases by 65%.