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protease/hypoxia

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Faqja 1 nga 19 rezultatet

Use of Mesenchymal Stem Cells in Acute Respiratory Distress Syndrome Caused by COVID-19

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Identifikohuni Regjistrohu
A Study of Mesenchymal Stem Cells as a treatment in Patients with Acute Respiratory Distress Syndrome caused by COVID-19 is a pilot phase, open label, non-randomized study, with a single study center. The current pandemic caused by the novel virus SARS-CoV-2 has lead to a health care crisis

PROSAIC-19 - Prospective Longitudinal Assessment in a COVID-19 Infected Cohort

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Identifikohuni Regjistrohu
INTRODUCTION 1.1 BACKGROUND Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is a new rapidly spreading infectious disease with no proven treatment options. The virus causes a spectrum of disease ranging from mild coryzal symptoms to severe respiratory compromise requiring

MicroRNAs in Renal Recovery - Pilot Study

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Identifikohuni Regjistrohu
Acute kidney injury (AKI) occurs in almost 50% of patients treated in intensive care units. AKI mainly occurs after sepsis, acute ischemia, nephrotoxicity or hypoxia and leads to severe damage of the kidney and to an increased risk of mortality. The diagnosis of AKI is currently based on creatinine,

COVID-19 Pneumonitis Low Dose Lung Radiotherapy (COLOR-19)

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Identifikohuni Regjistrohu
BACKGROUND Since the first case of Severe Acute Respiratory Syndrome - Coronavirus - 2 (SARS-CoV-2) infection and its subsequent clinical manifestation (COronaVIrus Disease 19, COVID-19) in the city of Wuhan (Hubei, China) in December 2019, contagion abruptly spread to different regions of China

Assessment of Disease Severity, Progression and Treatment in Infected Patients Presenting to the Emergency Department

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Identifikohuni Regjistrohu
Despite significant improvements in diagnostic and preventative measures, the incidence of sepsis has continued to escalate rapidly in hospitalized patients, with mortality rates ranging between 10 - 54%, depending on the level of severity. The earliest possible identification and assessment of

The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients

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Identifikohuni Regjistrohu
In a prospective, randomized clinical trial of de novo mandibular fracture patients requiring intraoral surgical repair with plating, the investigators will: 1. Compare the effects of supplemental vitamin C to placebo on soft tissue wound healing, measured by a) biomarkers of soft tissue repair

Morphine or/and Ketamine in Out-of-hospital Cardiac Arrest

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Identifikohuni Regjistrohu
Almost 35 years ago, Dr Peter Safar wrote that "cerebral recovery from more than 5 min of cardiac arrest is hampered by complex secondary derangements of multiple organ systems after reperfusion". Actually, these 5 "golden" minutes determine the ability of cerebral neurones to regain ordinary

Inhibition of SENP1 for the Suppression of OS Growth and Metastasis

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Identifikohuni Regjistrohu
Background: Osteosarcoma (OS) is the most common type of primary malignant bone tumor in children and adolescents. The overall survival rate is dramatically reduced by the development of metastases, often pulmonary. Solid malignant tumors, such as OS, often develop a hypoxic microenvironment, which

Disorders of the Acute Phase Response Following Trauma and Invasive Surgery

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Identifikohuni Regjistrohu
Significance: Severe injury is a leading cause of death and disability worldwide, affecting approximately 2.8 million individuals and accounting for over 200,000 deaths annually across the United States. Large cohort studies have demonstrated that approximately 64% of trauma-related deaths are due

Acute Kidney Injury in Newborns With Perinatal Asphyxia

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Identifikohuni Regjistrohu
Acute Kidney Injury is defined as the inability of the kidneys to excrete nitrogenous waste products and maintain fluid and electrolyte homeostasis. It is fairly common in newborn population and is a major contributor factor of neonatal mortality and morbidity. The most common form of Acute Kidney

Defining the Temporal Changes in the Acute Phase Response During Graded Exercise: A Prospective Study

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Identifikohuni Regjistrohu
Injury, ranging from a paper cut that barely splits the skin to a high-speed motor vehicle accident that rips through muscle and bone, causes a disruption of tissue compartments. This breach of compartments disposes tissue to four principle problems: 1) bleeding, 2) susceptibility to infection, 3)

Acute Kidney Injury After Cardiac Surgery

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Identifikohuni Regjistrohu
The usual diagnostic markers of AKI are defaulted. Indeed, oliguria tends to overstate the impact of AKI, up to 40-50% of patients. Postoperative increased serum creatinine is a late marker for the AKI. Furthermore, perioperative hemodilution and serum creatinine kinetic delay the postoperative peak

Genes-in-Action - Hepcidin Regulation of Iron Supplementation

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Identifikohuni Regjistrohu
Anaemia is a recalcitrant problem in global health, affecting particularly children and childbearing women in sub-Saharan Africa. Anaemia causes impaired growth and cognitive development in children, poor pregnancy outcomes including both maternal and perinatal mortality. Also, it is associated with

Arterial Blood Gas Analysis in Laparoscopic Cholecystectomy

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Identifikohuni Regjistrohu
Laparoscopic cholecystectomy procedure is the treatment of choice for cholelithiasis as it has several advantages like smaller and more cosmetic incision, reduced blood loss, less postoperative pain, reduced post-operative stay, low post-operative complications, and early mobilization. Although this

Proadrenomedullin for Early Risk Assessment in the Emergency Department

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Identifikohuni Regjistrohu
Emergency departments (ED) are becoming increasingly over-crowded, with patients facing prolonged waiting times. This is further aggravated by the shortage of available hospital space. Therefore, a safe and rapid triaging of patients is essential in improving the workflow within the ED, maximizing
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