*Less than 29 weeks Gestational Age (GA) preemies (100)
DCS monitoring will be performed for up to 72 hours starting within 2 days after birth. In a subgroup of infants, we will also perform additional measurements with aEEG and FDNIRS. At a second stage we will add Transcranial Doppler Ultrasound (TCD)

Premature Birth

Extremely Low Birth Weight

Infant, Small for Gestational Age

Intracerebral Hemorrhage

Diffuse correlation spectroscopy uses light in the near infrared spectral region to quantify non-invasively cerebral blood flow. The DCS device will be use to monitor blood flow changes over time in all ELGA enrolled babies

Diffuse Correlation Spectroscopy (DCS)

Amplitude Integrated Electroencephalography like EEG it is used clinically to monitor brain function in intensive care settings over longer periods of time. aEEG data will be correlated with CBF variation over time

Amplitude Integrated Electroencephalography (aEEG)

Brigham and Women's Hospital

DCS Study in Extremely Premature Newborns

The Continuous Monitoring of Cerebral Function, Oxygen Perfusion and Consumption in Extremely Premature Newborns

Test the feasibility of DCS monitoring of cerebral perfusion in extremely premature infants during the first few days of life.

To assess if cerebral blood flow disturbances measured with DCS correlate with incidence of intraventricular hemorrhage.

Correlate the DCS findings with clinical outcome at hospital discharge

Maria Angela Franceschini

professor

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Approximately 1.5% of infants born every year in the United States are born at an extremely low gestational age (ELGA <29 weeks GA). As reported in the 2015 VON database, the risk for developing any grade of intraventricular hemorrhage (IVH) in ELGA infants is about 20% and in more than 90% of these cases it occurs during the first three postnatal days. The major risk factor for IVH is the gestational age of the infant with greater immaturity being associated with the highest risk. The degree of prematurity of the infant relates to the immaturity of the vascular bed within the germinal matrix as well as challenges in the regulation of the cerebrovascular circulation. Specifically, increases, decreases and significant fluctuations in cerebral blood flow (CBF) have been shown to play important pathogenic roles in IVH. We are investigating the possibility of using a novel optical method to quantify cerebral perfusion, continuously, at the bedside in the NICU preterm population.

To test the magnitude by which short-term (4 weeks) sympathetic nerve activity blockade (clonidine) improves large elastic artery stiffness, vascular inflammation and baroreflex function in subjects with moderate-to-high levels of anxiety

Hydrochlorothiazide is a blood pressure-lowering control condition to compare to the effects of clonidine

Anxiety

Hypertension

Clonidine Pill

Blood pressure-lowering control condition

Hydrochlorothiazide

University of Iowa

Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System

Aortic stiffness as determined by the carotid-femoral pulse wave velocity technique

Seth Holwerda

Postdoctoral Research Fellow

NSTEMI

Colchicine

Placebo

Tel Aviv Medical Center

Sourasky medical center (Ichilov)

COlchicine Improve EnDothElial Function in Non ST Elevation Myocardial Infarction Patients

Does COlchicine Improve EnDothElial Function in Non ST Elevation Myocardial Infarction Patients?: A Prospective Randomized, Double-blind Placebo Controlled Study

RH-PAT will be measured before the angiography and after one month.

biomarkers will be assessed before and after the angiography. Comparison of the biomarker levels will be assessed between the two treatment groups

serum ICAM VACAM and endothelin will be measured

serum ACHE will be measured at randomization and after one month

AKI will be defined per AKIN as an increase of 0.3mg/dl. The two treatment groups will be compared

The investigators will assess this outcome using a standard quality of life questionnaire (EQ5).

Safety will be assessed by comparing adverse events between the two groups

psychomotor agitation/infarkti

DCS Study in Extremely Premature Newborns

Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System

COlchicine Improve EnDothElial Function in Non ST Elevation Myocardial Infarction Patients

A Trial of Long-Acting Injectable Risperidone in the Treatment of Methamphetamine Dependence

Baza e të dhënave më e plotë e bimëve medicinale e mbështetur nga shkenca