Standard supportive treatment (Oxygen, Enoxaparine, antibiotic, fluid, immune modulator (Steroid) and or antiviral (favipiravir or ramdesivir or lopinavir + ritonavir)

Standard supportive treatment + 200 ml apheretic convalescent plasma single transfusion

Standard supportive treatment + 400 ml apheretic convalescent plasma single transfusion

Covid19

Convalescence

Apheretic convalescent plasma from a COVID-19 survivor

Convalescent plasma

Bangabandhu Sheikh Mujib Medical University

Convalescent Plasma Therapy in Severe COVID-19 Infection

Convalescent Plasma Transfusion Therapy in Severe COVID-19 Patients- a Tolerability, Efficacy and Dose-response Phase II RCT

Temperature in degree Fahrenheit at Day 0, 1, 3, 7

Respiratory rate per minute at Day 0, 1, 3, 7

Saturation of oxygen in % at Day 0, 1, 3, 7

Blood pressure in mm of Hg at Day 0, 1, 3, 7

Oxygen requirements in liter/min at Day 0, 1, 3, 7

Requirement of ventilator support in hours

% of patients developed early transfusion reaction like fever, sweating, rash, abdominal pain, urticaria, vomiting, wheezing, chest tightness and hypotension

Data will be shared with the journal authority and make public as part of the publication

Fazle Rabbi Chowdhury

Assistant Professor

Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Dhaka Medical College

Arm-A: Standard supportive treatment; Arm-B: Standard supportive treatment + CP 200 ml; Arm C: Standard supportive treatment + CP 400 ml

Dry Eye

Autologous Plasma Eye Drop

Singapore Eye Research Institute

Autologous Plasma Treatment for Severe Dry Eye Patients

Use of Autologous Plasma Eyedrops Therapy for Severe Dry Eye in Singapore

A Visual Analogue Scale (VAS) will be applied to evaluate dry eye symptoms as described by Schaumberg et al. (Schaumberg 2007). As shown in Appendix B , the scores will be recorded separately for frequency and severity of dry eye symptoms. The patient will be asked to check a point on a 100-mm line that corresponds to the degree of the symptom. The location of the mark made by the patient for each question will be measured in mm from the left hand side of the 100 mm line and recorded in mm. For the follow up visits, which measured the distance between the mark made by the patient and the central anchor, a negative value will be recorded if left of the anchor and a positive value if right of the anchor. The higher the number, implying more symptoms and frequency of experiencing dry eye.
A global score will be calculated by multiplying the frequency score by the severity score and taking the square root of the result (to transform back to the original scale).

syphilis/nausea

Convalescent Plasma Therapy in Severe COVID-19 Infection

Autologous Plasma Treatment for Severe Dry Eye Patients

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