Bulletin of Experimental Biology and Medicine 2012-Nov
Cardioprotective properties of dimethyl sulfoxide during global ischemia-reperfusion of isolated rat heart.
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Cardioprotective properties of dimethyl sulfoxide (DMSO) were studied in the isolated rat heart model. Intraperitoneal administration of DMSO to animals for 3 days before the experiment, but not addition of DMSO to the perfusate, reduced infarction size. Both intraperitoneal and intracoronary administration of DMSO reduced the severity of postischemic left-ventricular dysfunction.