[Clinical effect of Xinqingning combined low dose continuous gastrointestinal dialysis in treating uremia].

OBJECTIVE

To investigate the clinical effect of Xinqingning (XQN), a preparation of rhubarb, combined with low dose continuous gastrointestinal dialysis in treating uremia.

METHODS

Patients of uremia were divided into three groups at random, eighteen patients in the group A were treated with 1000 ml gastrointestinal dialysate (non-absorbed mannitol solution) orally 2-3 times a day, twenty patients in the group B treated with the same therapy as that in the group A, but combined with XQN 5-10 tablets 3 times per day and 19 patients in the group C treated by orally taken coated aldehyde oxystarch 5-10 g, 3 times a day. The therapeutic course for the three groups were 11 months. The changes in clinical manifestation, renal function, nutritional condition, and electrolytes before and after treatment were observed.

RESULTS

After treatment, significant improvement was revealed in aspects of uremic symptoms, quality of life, nutritional condition, serum creatinine, urea nitrogen, serum phosphate, uric acid, CO2 combining power, creatine clearance, body weight and arm muscular circumference in the group A and B, as compared with those in the group C. In comparison of the group A and B, the group B showed a lower serum triglyceride and slower progression of chronic renal failure (CRF). All the criteria were not improved in the group C and with serum creatinine raised significantly.

CONCLUSIONS

XQN combined low dose continuous gastrointestinal dialysis therapy was effective in definitely treating uremia, it provides a new therapeutic means of non-replacement therapy for CRF with uremia.