[Clinical observation and preliminary study of termination of early pregnancy by administration of yellow daphne].

74 cases of early pregnancy with periods of amenorrhea of 36-69 days from the last menses were terminated by using a single dose intrauterine instillation of Wikstro-Emia Chamaedaphne Meisn Alcohol Solution (WCMAS). According to the dosages used, they were divided into 3 groups: 0.2gm, 0.4gm, and 0.6gm of WCMAS. The efficacy of the different dosages was evaluated. The most successful in the termination of early pregnancy (less than 56 days) was the 0.4gm group, the effective rate being 96.6%, and the complete abortion rate being 93.3%. The average duration of complete abortion in all was 21.3 hours, and the averge duration of vaginal bleeding was 10.9 days. Although amount of bleeding was regarded as a little greater than that of normal menstruation by some patients, yet there were no serious side effects occurring, except that some patients experienced some subjective lower abdominal pain and vomiting. Serum hCG and progesterone were determined by radioimmunoassay technique in 31 cases, and it was found that the hCG and progesterone levels both declined rapidly at 12 hours and fell to 35.5% and 46.4% respectively 24 hours after injection. Under microscopic examinations necrotic degeneration was observed in most of the chorionic villi, and marked necrosis and hemorrhage in the decidua. The granulocytes in the decidua also decreased in amount. 48 cases were followed up recently; no side effects were found and there was no interference with re-pregnancy.