[Drug effect comparison of Rhubarb extract by the technology free of heating and the extracts form crude Rhubarb and from prepared Rhubarb].
Кључне речи
Апстрактан
OBJECTIVE
To study the effects of rhubarb extract by the technology free of heating (RETFH) and the extracts from crude rhubarb and from prepared rhubarb on intestine movement and analgesia in mice, and to compare the effects each other.
METHODS
Intestine movement was studied by determining the distance in intestine after administrating the extracts from different technology with ink as indicator. Analgesia effect was studied by hot plate test and torsion test induced by acetic acid for the extracts from different technology.
RESULTS
Diarrhea effect of low dose (0.75 mg/g) RETFH was moderate, and equal to that of high dose (3.00 mg/g) extract from prepared rhubarb. Remarkable analgesia effect of low dose (0.50 mg/g) RETFH was equal to that of middle and high dose (2.00 mg/g, 4.00 mg/g) extracts from prepared rhubarb and high dose (4.00 mg/g) extract from crude rhubarb.
CONCLUSIONS
0.50 mg/g RETFH possessed obvious diarrhea and analgesia effects. To utilize the technology free of heating may decrease dosage of rhubarb and save medicinal resource.
