High corn oil dietary intake improves health and longevity of aging mice.

Corn oil has been recommended as a replacement for saturated fats because of its high levels of poly- and mono-unsaturated fatty acids. In the present study, we tested whether very high levels of corn oil (58.6% fat-derived calories, FDC) intake improve health and longevity of aging mice. Twelve month old male C57BL/6 mice were fed a normal diet (10% FDC of corn oil, N) or a high fat diet (58.6% FDC of corn oil, HF) for 13-15 months. Our results show that a HF diet significantly increased the longevity of the aged mice (at 25 months of age, 53.8% of mice died in the N group, whereas the mortality rate was only 23.2% in the HF group). High corn oil also reversed aging-increased blood lipids including triglyceride, total cholesterol and LDL. Similarly, high corn oil intake overturned aging-raised pro-inflammatory markers including IL-1β, IL-6, and monocyte chemotactic protein-1 (MCP-1) in the blood. In addition, corn oil intake reversed aging-damaged rotarod performance and liver function. Interestingly, the HF group was significantly heavier than the N group (53.6g/mouse vs. 41.3g/mouse); however, both HF and N groups had the same calorie intake (12.48 kcal/d/mouse vs. 12.24 kcal/d/mouse). Although, the HF group's food consumption was lower than that of the N group (2.4 g/d/mouse vs. 3.4 g/d/mouse). These results suggest that if total calorie consumption stays in the normal range, very high levels of corn oil intake improve health and longevity of aging mice.