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BACKGROUND
Fibroblast-like synoviocytes (FLS) in the intimal lining of the joint synovium control the composition of the synovial fluid and extracellular matrix (ECM) of the joint lining. In rheumatoid arthritis (RA), FLS become aggressive and invasive, contributing to many aspects of RA pathology.
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to novel phosphotetrahydropyran compounds, primarily derivatives of mannose-6-phosphate, and their use in treating diseases or disorders that are mediated at least in part by T lymphocyte emigration from
The subject matter described herein was in part a subject invention of NIH Grants Nos. IR23AI23058-03, R01 AI-28175, R01 DE-12156, and P60 KD20542 of which the present inventor was the Principal Investigator and either the Donald Guthrie Foundation for Medical Research Inc. of Guthrie Square, Sayre,
FIELD OF THE PRESENT INVENTION
The present invention relates to the therapeutic and scientific uses for the human H4-1BB protein, its ligands, and the development of monoclonal antibodies that recognize and bind the H4-1BB receptor protein.
BACKGROUND OF THE PRESENT INVENTION
The immune system of