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cardiomyopathies/protease

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7 резултати

Respiratory Cathepsins, Proteases Inhibitors and Glycosaminoglycans (GAG) in Mucopolysaccharidosis

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Mucopolysaccharidosis (MPS) are a group of inherited, metabolic diseases caused by a deficiency of lysosomal enzymes that degrade glycosaminoglycans (GAGs). Loss of their activity results in cellular accumulation of GAGs fragments leading to progressive multi-system manifestations (central nervous

Effects of Incretins on Human Platelet Function

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Aims and Methods: The prevalence of Type 2 diabetes (T2D) continues to increase globally and brings with it a parallel increase in the associated cardiovascular disease complications. Correction of platelet hyperactivity holds promise for this high-risk population of T2D patients by contributing to

Circulating Markers for Ischemic Heart Disease

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Hypotheses, Objectives and Aims: Hypotheses:Caspase-3, cleaved and activated, and dystrophin can be detected in human circulation. The levels of these two markers are elevated during acute myocardial infarction. Furthermore, the levels of these two proteins are greater in those who develop heart

Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure

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Heart failure (HF) is a complex clinical syndrome and major public health problem claiming the lives of >500,000 per year. It is the leading Diagnosis Related Group (DRG) for hospital discharges in the US. There are approximately 1-3 million admissions annually for acute decompensated heart failure.

Safety and Efficacy Study of Switching From Epzicom to Truvada

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This protocol describes a prospective, randomized, open-label, multicenter study to evaluate the safety and efficacy of switching from fixed dose ABC/3TC to fixed dose FTC/TDF in virologically suppressed, HIV-1 infected subjects maintained on a PI/r-containing ARV regimen. Subjects were stratified

Allograft Fibrosis Following Pediatric Cardiac Transplantation

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There has been recent evidence that demonstrates a significant racial disparity in outcomes following pediatric heart transplantation.Differences in fibrosis or its regulation may offer an explanation to these differences.Just as the pathologic alterations of cardiac connective tissue in the

Relationship Between Fatigue and Mitochondrial Damage in Patients With HIV/AIDS

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Both HIV infection and antiretroviral nucleoside analogues (nucleoside reverse transcriptase inhibitors or NRTIs) are known to affect mitochondrial DNA content and mitochondrial function. A number of important clinical syndromes observed in HIV-infected persons relate to mitochondrial dysfunction
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